Folding dynamics of polymorphic G‐quadruplex structures
| العنوان: | Folding dynamics of polymorphic |
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| المؤلفون: | J Tassilo Grün, Harald Schwalbe |
| المصدر: | Biopolymers. 113 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Chemistry, Organic Chemistry, Biophysics, Cell regulation, Energy landscape, DNA, General Medicine, Computational biology, G-quadruplex, Biochemistry, G-Quadruplexes, Biomaterials, Folding (chemistry), chemistry.chemical_compound, Transcription (biology), Humans, Human genome, Chromosomal dna |
| الوصف: | G-quadruplexes (G4), found in numerous places within the human genome, are involved in essential processes of cell regulation. Chromosomal DNA G4s are involved for example, in replication and transcription as first steps of gene expression. Hence, they influence a plethora of downstream processes. G4s possess an intricate structure that differs from canonical B-form DNA. Identical DNA G4 sequences can adopt multiple long-lived conformations, a phenomenon known as G4 polymorphism. A detailed understanding of the molecular mechanisms that drive G4 folding is essential to understand their ambivalent regulatory roles. Disentangling the inherent dynamic and polymorphic nature of G4 structures thus is key to unravel their biological functions and make them amenable as molecular targets in novel therapeutic approaches. We here review recent experimental approaches to monitor G4 folding and discuss structural aspects for possible folding pathways. Substantial progress in the understanding of G4 folding within the recent years now allows drawing comprehensive models of the complex folding energy landscape of G4s that we herein evaluate based on computational and experimental evidence. |
| تدمد: | 1097-0282 0006-3525 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66cd556c6803005e9465ecb8cc41dbd0 https://doi.org/10.1002/bip.23477 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....66cd556c6803005e9465ecb8cc41dbd0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970282 00063525 |
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