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FUROSEMIDE AND SPIRONOLACTONE REDUCE TRANSMIGRATION OF LEUKOCYTES THROUGH ENDOTHELIAL CELL MONOLAYERS

التفاصيل البيبلوغرافية
العنوان: FUROSEMIDE AND SPIRONOLACTONE REDUCE TRANSMIGRATION OF LEUKOCYTES THROUGH ENDOTHELIAL CELL MONOLAYERS
المؤلفون: Roland Hofbauer, Stylianos Kapiotis, Alan D. Kaye, Bernhard Gmeiner, Michael Frass, Eva Pasching
المصدر: Journal of Toxicology and Environmental Health, Part A. 65:685-693
بيانات النشر: Informa UK Limited, 2002.
سنة النشر: 2002
مصطلحات موضوعية: Male, medicine.medical_specialty, Leukocyte migration, Neutrophils, Health, Toxicology and Mutagenesis, Inflammation, Spironolactone, Toxicology, Umbilical vein, chemistry.chemical_compound, Cell Movement, Furosemide, Internal medicine, Cell Adhesion, medicine, Humans, Diuretics, Cell adhesion, business.industry, Infant, Newborn, Cell Migration Inhibition, Fetal Blood, Coculture Techniques, Endothelial stem cell, Endocrinology, chemistry, Depression, Chemical, Female, Endothelium, Vascular, medicine.symptom, business, medicine.drug
الوصف: Furosemide and spironolactone reduce transmigration of leukocytes through endothelial cell monolayers. Leukocytes play a tremendous role during inflammation. Leukocytes migrate from intravascular space into the tissue to attack microorganisms. Various agents are able to influence leukocyte recruitment. The influence of diuretics, such as furosemide and spironolactone, on inflammatory processes is not well known. The aim of our study was to examine the influence of furosemide and spironolactone on leukocyte migration through endothelial cell monolayers (ECM). Human umbilical vein endothelial cells were cultured on microporous membranes achieving a monolayer. Polymorphonuclear leukocytes (PMNL) were used in a currently described migration assay. PMNL and/or ECM were pretreated with furosemide and spironolactone using therapeutic, as well as higher and lower, concentrations. Furosemide (76 +/- 7.2%) and spironolactone (70 +/- 7.7%) were able to inhibit PMNL migration through ECM significantly, when both cell types were treated simulating the situation after an iv injection. Furosemide and spironolactone were identified as potent inhibitors of leukocyte migration through ECM.
تدمد: 1087-2620
1528-7394
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d9d3423fb4793c3b1209cd29d9cfef
https://doi.org/10.1080/15287390252900386
رقم الأكسشن: edsair.doi.dedup.....66d9d3423fb4793c3b1209cd29d9cfef
قاعدة البيانات: OpenAIRE
الوصف
تدمد:10872620
15287394