Maternal overweight before pregnancy and asthma in offspring followed for 8 years
العنوان: | Maternal overweight before pregnancy and asthma in offspring followed for 8 years |
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المؤلفون: | Scholtens, S., Wijga, A.H., Brunekreef, B., Kerkhof, M., Postma, D.S., Oldenwening, M., de Jongste, J.C., Smit, H.A., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS |
المساهمون: | Groningen Research Institute for Asthma and COPD (GRIAC), Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Pediatrics |
المصدر: | International Journal of Obesity, 34(4), 606-613. Nature Publishing Group International Journal of Pediatric Obesity, 34, 606-613. Wiley-Blackwell for the International Association for the Study of Obesity International Journal of Obesity, 34(4), 606. Nature Publishing Group |
بيانات النشر: | Nature Publishing Group, 2010. |
سنة النشر: | 2010 |
مصطلحات موضوعية: | Male, Pediatrics, Endocrinology, Diabetes and Metabolism, CHILDHOOD, Medicine (miscellaneous), CHILDREN, Overweight, Body Mass Index, birth cohort study, Surveys and Questionnaires, Child, Nutrition and Dietetics, INCIDENT ASTHMA, PREVALENCE, ALLERGY, Child, Preschool, OBESITY, Female, Disease Susceptibility, pregnancy, medicine.symptom, Inflammation Mediators, Cohort study, Adult, medicine.medical_specialty, Birth weight, Mothers, AGE, Internal medicine, Wheeze, medicine, Humans, overweight, Asthma, Pregnancy, business.industry, Infant, Newborn, Infant, Allergens, asthma, medicine.disease, Obesity, respiratory tract diseases, BODY-MASS INDEX, Endocrinology, WEIGHT, business, Epidemiologic Methods, RESPIRATORY-HEALTH, Body mass index |
الوصف: | Objective: The aim of this study was to investigate the association between maternal overweight before pregnancy and offspring asthma in an ongoing birth cohort study. Maternal overweight may affect the pulmonary and immunological development of the fetus in utero because of the increased levels of inflammatory factors associated with being overweight and thereby increase the asthma risk in childhood.Design: Birth cohort study with follow-up until 8 years of age.Subjects: The study population included 3963 children and their mothers who participated in the Prevention and Incidence of Asthma and Mite Allergy study.Measurements: Maternal overweight before pregnancy was defined as a body mass index (BMI) above 25 kgm(-2). Data on wheeze, dyspnea and prescription of inhaled corticosteroids of the child were reported yearly by the parents in a questionnaire. Sensitization to inhalant allergens and bronchial hyperresponsiveness (BHR) were determined at 8 years. Effect modification by predisposition for asthma in the child was tested. Data were analyzed by logistic regression and generalized estimating equations analyses.Results: At 8 years, 14.4% (n = 571) of the children had asthma. In total, 20.9% (n = 830) of the mothers were overweight before pregnancy. In children predisposed for asthma (n 1058), maternal overweight before pregnancy was associated with an increased risk of asthma in the child at 8 years (OR = 1.52, 95% CI: 1.05-2.18) after adjustment for confounding factors, birth weight and the child's BMI. No association was observed in children without a predisposition (OR = 0.86, 95% CI: 0.60-1.23). There was no association with sensitization or BHR.Conclusion: Children with a predisposition for asthma may have a higher risk to develop asthma during childhood when their mothers are overweight before pregnancy, irrespective of the child's BMI. International Journal of Obesity (2010) 34, 606-613; doi: 10.1038/ijo.2009.194; published online 29 September 2009 |
وصف الملف: | application/pdf |
اللغة: | English |
تدمد: | 1476-5497 0307-0565 1747-7166 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::670c1a768e76174efa0313047963ee1f https://research.rug.nl/en/publications/d1788d20-95df-416e-bca8-14c44e98fb59 |
حقوق: | OPEN |
رقم الأكسشن: | edsair.doi.dedup.....670c1a768e76174efa0313047963ee1f |
قاعدة البيانات: | OpenAIRE |
تدمد: | 14765497 03070565 17477166 |
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