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Maternal overweight before pregnancy and asthma in offspring followed for 8 years

التفاصيل البيبلوغرافية
العنوان: Maternal overweight before pregnancy and asthma in offspring followed for 8 years
المؤلفون: Scholtens, S., Wijga, A.H., Brunekreef, B., Kerkhof, M., Postma, D.S., Oldenwening, M., de Jongste, J.C., Smit, H.A., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS
المساهمون: Groningen Research Institute for Asthma and COPD (GRIAC), Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Pediatrics
المصدر: International Journal of Obesity, 34(4), 606-613. Nature Publishing Group
International Journal of Pediatric Obesity, 34, 606-613. Wiley-Blackwell for the International Association for the Study of Obesity
International Journal of Obesity, 34(4), 606. Nature Publishing Group
بيانات النشر: Nature Publishing Group, 2010.
سنة النشر: 2010
مصطلحات موضوعية: Male, Pediatrics, Endocrinology, Diabetes and Metabolism, CHILDHOOD, Medicine (miscellaneous), CHILDREN, Overweight, Body Mass Index, birth cohort study, Surveys and Questionnaires, Child, Nutrition and Dietetics, INCIDENT ASTHMA, PREVALENCE, ALLERGY, Child, Preschool, OBESITY, Female, Disease Susceptibility, pregnancy, medicine.symptom, Inflammation Mediators, Cohort study, Adult, medicine.medical_specialty, Birth weight, Mothers, AGE, Internal medicine, Wheeze, medicine, Humans, overweight, Asthma, Pregnancy, business.industry, Infant, Newborn, Infant, Allergens, asthma, medicine.disease, Obesity, respiratory tract diseases, BODY-MASS INDEX, Endocrinology, WEIGHT, business, Epidemiologic Methods, RESPIRATORY-HEALTH, Body mass index
الوصف: Objective: The aim of this study was to investigate the association between maternal overweight before pregnancy and offspring asthma in an ongoing birth cohort study. Maternal overweight may affect the pulmonary and immunological development of the fetus in utero because of the increased levels of inflammatory factors associated with being overweight and thereby increase the asthma risk in childhood.Design: Birth cohort study with follow-up until 8 years of age.Subjects: The study population included 3963 children and their mothers who participated in the Prevention and Incidence of Asthma and Mite Allergy study.Measurements: Maternal overweight before pregnancy was defined as a body mass index (BMI) above 25 kgm(-2). Data on wheeze, dyspnea and prescription of inhaled corticosteroids of the child were reported yearly by the parents in a questionnaire. Sensitization to inhalant allergens and bronchial hyperresponsiveness (BHR) were determined at 8 years. Effect modification by predisposition for asthma in the child was tested. Data were analyzed by logistic regression and generalized estimating equations analyses.Results: At 8 years, 14.4% (n = 571) of the children had asthma. In total, 20.9% (n = 830) of the mothers were overweight before pregnancy. In children predisposed for asthma (n 1058), maternal overweight before pregnancy was associated with an increased risk of asthma in the child at 8 years (OR = 1.52, 95% CI: 1.05-2.18) after adjustment for confounding factors, birth weight and the child's BMI. No association was observed in children without a predisposition (OR = 0.86, 95% CI: 0.60-1.23). There was no association with sensitization or BHR.Conclusion: Children with a predisposition for asthma may have a higher risk to develop asthma during childhood when their mothers are overweight before pregnancy, irrespective of the child's BMI. International Journal of Obesity (2010) 34, 606-613; doi: 10.1038/ijo.2009.194; published online 29 September 2009
وصف الملف: application/pdf
اللغة: English
تدمد: 1476-5497
0307-0565
1747-7166
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::670c1a768e76174efa0313047963ee1f
https://research.rug.nl/en/publications/d1788d20-95df-416e-bca8-14c44e98fb59
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....670c1a768e76174efa0313047963ee1f
قاعدة البيانات: OpenAIRE
الوصف
تدمد:14765497
03070565
17477166