Acute Effect of Lidocaine on Coronary Blood Flow and Myocardial Function
| العنوان: | Acute Effect of Lidocaine on Coronary Blood Flow and Myocardial Function |
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| المؤلفون: | David Gee, Richard A. Wilson, Debra A. Angello |
| المصدر: | Angiology. 41:30-35 |
| بيانات النشر: | SAGE Publications, 1990. |
| سنة النشر: | 1990 |
| مصطلحات موضوعية: | Time Factors, Lidocaine, Swine, Hemodynamics, Blood Pressure, 030204 cardiovascular system & hematology, 03 medical and health sciences, Oxygen Consumption, 0302 clinical medicine, Bolus (medicine), Heart Rate, Coronary Circulation, Heart rate, Animals, Medicine, 030212 general & internal medicine, business.industry, Blood flow, Myocardial Contraction, medicine.anatomical_structure, Anesthesia, Circulatory system, Vascular resistance, Vascular Resistance, Cardiology and Cardiovascular Medicine, business, medicine.drug, Blood vessel |
| الوصف: | The acute effects of lidocaine on coronary blood flow, hemodynamic parameters, and wall function were studied in 14 anesthetized pigs. Lidocaine was infused intravenously as a bolus (dosage range from 1.5 to 4.0 mg/kg). At ten to thirty seconds after infusion, coronary blood flow reached 154 +/- 38% (mean +/- SD) of the baseline resting flow (p less than 0.001). The double product, an estimate of myocardial oxygen demand, decreased from a baseline value of 9221 +/- 2174 to 8008 +/- 1923 mmHg beats/min (p less than 0.01). Sixty seconds postinfusion myocardial function decreased from baseline wall thickening of 46 +/- 25% to 41 +/- 17% (p = 0.04). An acute bolus of lidocaine appears to transiently increase coronary blood flow, by decreasing coronary vascular resistance, and also decrease myocardial function. Thus, an acute lidocaine bolus may favorably alter the myocardial oxygen supply/demand ratio. |
| تدمد: | 1940-1574 0003-3197 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6785cb9aa49fca7e02570c486e2be4db https://doi.org/10.1177/000331979004100105 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....6785cb9aa49fca7e02570c486e2be4db |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19401574 00033197 |
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