Molecular and cellular mechanisms underlying defective antibody responses
| العنوان: | Molecular and cellular mechanisms underlying defective antibody responses |
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| المؤلفون: | Julia Bier, Alisa Kane, Anthony Lau, Elissa K. Deenick |
| المصدر: | Immunology & Cell Biology. 98:467-479 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | B-Lymphocytes, Primary Immunodeficiency Diseases, Immunology, Immunologic Deficiency Syndromes, Autoimmunity, Cell Biology, biochemical phenomena, metabolism, and nutrition, Biology, medicine.disease_cause, medicine.disease, Antibody production, Antibody response, Immune system, Antibody Formation, Humoral immunity, medicine, biology.protein, Humans, Immunology and Allergy, Antibody, Function (biology), Immunodeficiency |
| الوصف: | Primary immune deficiency is caused by genetic mutations that result in immune dysfunction and subsequent susceptibility to infection. Over the last decade there has been a dramatic increase in the number of genetically defined causes of immune deficiency including those which affect B-cell function. This has not only identified critical nonredundant pathways that control the generation of protective antibody responses but also revealed that immunodeficiency and autoimmunity are often closely linked. Here we explore the molecular and cellular mechanisms of these rare monogenic conditions that disrupt antibody production, which also have implications for understanding the causes of more common polygenic immune dysfunction. |
| تدمد: | 1440-1711 0818-9641 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67911140c72100d0185529883c47e1f3 https://doi.org/10.1111/imcb.12345 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....67911140c72100d0185529883c47e1f3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14401711 08189641 |
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