Molecular Imaging, Pharmacokinetics, and Dosimetry of 111In-AMBA in Human Prostate Tumor-Bearing Mice
| العنوان: | Molecular Imaging, Pharmacokinetics, and Dosimetry of 111In-AMBA in Human Prostate Tumor-Bearing Mice |
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| المؤلفون: | Yu-Hsien Wu, I-Hsiang Liu, Wan-Chi Lee, Lie-Hang Shen, Liang-Cheng Chen, Te-Wei Lee, Chun-Lin Chen, Chung-Li Ho, Cheng-Hui Chuang, Wuu-Jyh Lin, Chih-Hsien Chang |
| المصدر: | Journal of Biomedicine and Biotechnology, Vol 2011 (2011) |
| بيانات النشر: | Hindawi Limited, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Biodistribution, Article Subject, business.industry, Health, Toxicology and Mutagenesis, lcsh:Biotechnology, lcsh:R, lcsh:Medicine, General Medicine, Effective dose (pharmacology), In vitro, medicine.anatomical_structure, Pharmacokinetics, Prostate, lcsh:TP248.13-248.65, Genetics, medicine, Molecular Medicine, Distribution (pharmacology), Personalized medicine, Molecular imaging, business, Nuclear medicine, Molecular Biology, Biotechnology |
| الوصف: | Molecular imaging with promise of personalized medicine can provide patient-specific information noninvasively, thus enabling treatment to be tailored to the specific biological attributes of both the disease and the patient. This study was to investigate the characterization of DO3A-CH2CO-G-4-aminobenzoyl-Q-W-A-V-G-H-L-M-NH2(AMBA)in vitro, MicroSPECT/CT imaging, and biological activities of111In-AMBA in PC-3 prostate tumor-bearing SCID mice. The uptake of111In-AMBA reached highest with3.87±0.65% ID/g at 8 h. MicroSPECT/CT imaging studies suggested that the uptake of111In-AMBA was clearly visualized between 8 and 48 h postinjection. The distribution half-life (t1/2α) and the elimination half-life (t1/2β) of111In-AMBA in mice were 1.53 h and 30.7 h, respectively. TheCmaxand AUC of111In-AMBA were 7.57% ID/g and 66.39 h∗% ID/g, respectively. The effective dose appeared to be 0.11 mSv/MBq-1. We demonstrated a good uptake of111In-AMBA in the GRPR-overexpressed PC-3 tumor-bearing SCID mice.111In-AMBA is a safe, potential molecular image-guided diagnostic agent for human GRPR-positive tumors, ranging from simple and straightforward biodistribution studies to improve the efficacy of combined modality anticancer therapy. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 1110-7251 1110-7243 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6794d59f35703a387b0aa54c43071f25 https://doaj.org/article/fbb67d7029a249b9b66a3f71492d57a2 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6794d59f35703a387b0aa54c43071f25 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 11107251 11107243 |
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