Expression of the Ubiquitin Ligase Subunit Cyclin Kinase Subunit 1 and its Relationship to S-Phase Kinase Protein 2 and p27 Kip1 in Prostate Cancer
| العنوان: | Expression of the Ubiquitin Ligase Subunit Cyclin Kinase Subunit 1 and its Relationship to S-Phase Kinase Protein 2 and p27 Kip1 in Prostate Cancer |
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| المؤلفون: | Ofer Ben-Izhak, Merav Slotky, Oleg Goldin, Dan D. Hershko, Shirly Lahav-Baratz, Ma'anit Shapira |
| المصدر: | Journal of Urology. 176:2285-2289 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Aged, 80 and over, Male, MAP kinase kinase kinase, Cyclin-dependent kinase 4, Urology, Cyclin-dependent kinase 2, Cyclin-dependent kinase 3, Prostatic Neoplasms, Middle Aged, Biology, Mitogen-activated protein kinase kinase, Cyclin-Dependent Kinases, CDC2-CDC28 Kinases, Cancer research, Cyclin-dependent kinase complex, biology.protein, Humans, Cyclin-dependent kinase 9, Cyclin-dependent kinase 7, Carrier Proteins, S-Phase Kinase-Associated Proteins, Cyclin-Dependent Kinase Inhibitor p27, Aged |
| الوصف: | Loss of the cell cycle inhibitory protein p27Kip1 in cancer is associated with tumor aggressiveness and poor prognosis in the prostate. The decrease in p27(Kip1) results from increased proteasome dependent degradation, which is mediated by its specific ubiquitin ligase subunits S-phase kinase protein 2 and cyclin dependent kinase subunit 1. S-phase kinase protein 2 was found to be over expressed in aggressive prostate cancers but to our knowledge the role of cyclin dependent kinase subunit 1 in these cancers is unknown.The expression of cyclin dependent kinase subunit 1, S-phase kinase protein 2 and p27Kip1 was examined by immunohistochemistry in tissue sections from 45 patients with prostate cancer. The expression of cyclin dependent kinase subunit 1 was compared to that of S-phase kinase protein 2 and p27Kip1, and patient clinical and histological characteristics.Cyclin dependent kinase subunit 1 expression was strongly associated with S-phase kinase protein 2 expression (r = 0.666, p = 0.001) and inversely with p27Kip1 expression (r = -0.737, p0.001). Cyclin dependent kinase subunit 1 over expression was associated with loss of tumor differentiation (r = 0.631, p = 0.001), high serum prostate specific antigen (r = 0.627, p0.001) and metastatic disease (p0.001).These results suggest that cyclin dependent kinase subunit 1 is involved in p27Kip1 down-regulation and it may have an important causative role in the development of aggressive tumor behavior in prostate cancer. |
| تدمد: | 1527-3792 0022-5347 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a19f400f1d85b82c62161beac39979 https://doi.org/10.1016/j.juro.2006.07.051 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....67a19f400f1d85b82c62161beac39979 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15273792 00225347 |
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