Reduction Effect of Calcium Alginate on Blood Triglyceride Levels Causing the Inhibition of Hepatic and Total Body Accumulation of Fat in Rats
| العنوان: | Reduction Effect of Calcium Alginate on Blood Triglyceride Levels Causing the Inhibition of Hepatic and Total Body Accumulation of Fat in Rats |
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| المؤلفون: | Takako Kato, Fumiyoshi Kasahara, Yoko Idota, Takuo Ogihara, Chihiro Miyajima, Hiroshi Arakawa, Hitoe Takahashi, Chihaya Kakinuma, Kurt Hara, Kentaro Yano |
| المصدر: | Biological and Pharmaceutical Bulletin. 42:365-372 |
| بيانات النشر: | Pharmaceutical Society of Japan, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, Calcium alginate, Alginates, Pharmaceutical Science, Absorption (skin), Diet, High-Fat, Excretion, Feces, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, medicine, Animals, Lipase, Triglycerides, Alginic acid, Pharmacology, Dose-Response Relationship, Drug, Triglyceride, biology, Chemistry, Body Weight, Lipid metabolism, General Medicine, Lipid Metabolism, Rats, 030104 developmental biology, Endocrinology, Adipose Tissue, Liver, 030220 oncology & carcinogenesis, biology.protein |
| الوصف: | In this study, rats were fed a high-fat diet containing calcium alginate (Ca-Alg) for 5 weeks to examine the effects of Ca-Alg on lipid metabolism including triglyceride (TG) levels in the blood. We also investigated the mechanism of the TG-reducing effect of Alg in vitro. Rats were randomized into 5 groups: high-fat diet group (14% (w/w) lard, HF); three Ca-Alg-containing diet groups (2.5, 5 or 10% (w/w) Ca-Alg) and a resistant maltodextrin (RMD) diet group as a positive control (with 5% (w/w) RMD). The 10% Ca-Alg group showed a significant reduction of body weight increase from the 7th day. In addition, the increase of TG in blood was significantly suppressed, and the amount of TG excreted in feces was increased. Increase of body fat mass was in the order HF > RMD > Ca-Alg 2.5% > Ca-Alg 5% > Ca-Alg 10%, while the total weight of the extracted fat tissues was significantly reduced in the RMD, 5% and 10% Ca-Alg groups. Hepatic pathology showed clear circular vacuoles apparently representing TG accumulation in the HF group, while fewer vacuoles were seen in the Ca-Alg groups. The results of in vitro experiments indicated that Ca-Alg does not directly inhibit lipase activity, but may suppress absorption of TG by forming non-absorbable macromolecular micelles containing TG. These results suggest that Ca-Alg promotes excretion and suppresses absorption of TG, leading to reduced blood TG levels, and decreased hepatic and total body accumulation of fat. The findings should be helpful for designing future clinical trials. |
| تدمد: | 1347-5215 0918-6158 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a2c81329485025678e94480e9c1644 https://doi.org/10.1248/bpb.b18-00530 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....67a2c81329485025678e94480e9c1644 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13475215 09186158 |
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