MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation
| العنوان: | MAP4K Interactome Reveals STRN4 as a Key STRIPAK Complex Component in Hippo Pathway Regulation |
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| المؤلفون: | Han Han, Wenqi Wang, Xu Li, Bing Yang, Rebecca Vargas, Gayoung Seo |
| المصدر: | Cell reports, vol 32, iss 1 Cell Rep |
| بيانات النشر: | eScholarship, University of California, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Proteomics, Subfamily, Hippo pathway, Medical Physiology, Regulator, Interactome, STRIPAK, 0302 clinical medicine, Cluster Analysis, 2.1 Biological and endogenous factors, Protein Interaction Maps, Aetiology, Cancer, MAP4K, Kinase, Adaptor Proteins, STRN4, endometrial cancer, Female, YAP, Signal Transduction, Protein Binding, Biotechnology, Cell signaling, 1.1 Normal biological development and functioning, Computational biology, Biology, Protein Serine-Threonine Kinases, General Biochemistry, Genetics and Molecular Biology, Article, Cell Line, 03 medical and health sciences, Underpinning research, Humans, Hippo Signaling Pathway, Protein kinase A, Adaptor Proteins, Signal Transducing, Hippo signaling pathway, Signal Transducing, Reproducibility of Results, YAP-Signaling Proteins, Endometrial Neoplasms, 030104 developmental biology, Multiprotein Complexes, Calmodulin-Binding Proteins, Generic health relevance, Biochemistry and Cell Biology, 030217 neurology & neurosurgery, Transcription Factors |
| الوصف: | Mitogen-activated protein kinase kinase kinase kinases (MAP4Ks) constitute a mammalian STE20-like serine/threonine kinase subfamily. Recent studies provide substantial evidence for MAP4K family kinases in the Hippo pathway regulation, suggesting a broad role of MAP4Ks in human physiology and diseases. However, a comprehensive analysis of the regulators and effectors for this key kinase family has not been fully achieved. Using a proteomic approach, we define the protein-protein interaction network for human MAP4K family kinases and reveal diverse cellular signaling events involving this important kinase family. Through it, we identify a STRIPAK complex component, STRN4, as a generic binding partner for MAP4Ks and a key regulator of the Hippo pathway in endometrial cancer development. Taken together, the results of our study not only generate a rich resource for further characterizing human MAP4K family kinases in numerous biological processes but also dissect the STRIPAK-mediated regulation of MAP4Ks in the Hippo pathway. |
| وصف الملف: | application/pdf |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67cb5d9f98c82c4b9068af662836f773 https://escholarship.org/uc/item/7fn6480n |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....67cb5d9f98c82c4b9068af662836f773 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |