Cognitive and emotional impairment in patients with migraine and signs of leukoencephalopathy during preventive therapy
| العنوان: | Cognitive and emotional impairment in patients with migraine and signs of leukoencephalopathy during preventive therapy |
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| المؤلفون: | V. A. Parfenov, K. A. Pozhidaev |
| المصدر: | Nevrologiâ, Nejropsihiatriâ, Psihosomatika, Vol 12, Iss 6, Pp 19-25 (2020) |
| بيانات النشر: | IMA-PRESS LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, leukoencephalopathy, neuropsychological examination, Trail Making Test, Hospital Anxiety and Depression Scale, Benton Visual Retention Test, memory, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, magnetic resonance imaging, migraine, 030212 general & internal medicine, RC346-429, cognitive impairment, business.industry, Neuropsychology, Beck Depression Inventory, Montreal Cognitive Assessment, medicine.disease, anxiety, attention, Psychiatry and Mental health, Clinical Psychology, Migraine, depression, Anxiety, Neurology (clinical), Neurology. Diseases of the nervous system, medicine.symptom, business, headache, 030217 neurology & neurosurgery |
| الوصف: | Patients with migraine and signs of leukoencephalopathy are frequently found to have cognitive impairment (CI), the pathogenesis of which is not entirely clear. The dynamics of CI in these patients during preventive therapy has been little studied.Patients and methods. A six-month follow-up study was conducted in 50 patients (8 men and 42 women; mean age, 41.9±11.9 years) with migraine (mainly chronic one) and signs of cerebral leukoencephalopathy according to magnetic resonance imaging (MRI). A control group consisted of 40 healthy individuals (13 males and 27 females) aged 20 to 64 years (mean age, 42.6±12.0 years). Neuropsychological examinations (the 12-word recall test; the test of literal and categorical associations; the Benton visual retention test, the Munsterberg test; the Montreal Cognitive Assessment (MoCA), the trail making test; the forward and backward digit recall test; the digit-symbol coding test; and the Stroop color test) and studies of emotional disorders (the Beck Depression Inventory (BDI), the Center for Epidemiological Studies Depression Scale (CES-D); the Hospital Anxiety and Depression Scale (HADS), and the Spielberger-Khanin Scale) were performed at baseline, and at 3 and 6 months of preventive therapy for migraine.Results and discussion. The patients with migraine versus the control group were observed to have lower scores of the MoCA (p=0.004), the 12- word recall test (p=0.0003), and the tests of literal (p=0.001) and categorical (p=0.0002) associations. No significant relationship was found between the volume of MRI cerebral white matter lesions and the severity of CI. There was a moderate inverse correlation (correlation coefficient R=-0.41) between the number of headache (HA) days per month and the MoCA score (pConclusion. During preventive treatment for migraine, there was a reduction in the frequency of HA attacks and in the severity of emotional and cognitive impairment. The preventive treatment of migraine and related emotional disorders seems to be the most effective way to improve cognitive functions. |
| اللغة: | Russian |
| تدمد: | 2310-1342 2074-2711 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d48904647b192c9f19565ff76eadbc https://nnp.ima-press.net/nnp/article/view/1467 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....67d48904647b192c9f19565ff76eadbc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23101342 20742711 |
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