Conventional ICSI vs. physiological selection of spermatozoa for ICSI (picsi) in sibling oocytes
| العنوان: | Conventional ICSI vs. physiological selection of spermatozoa for ICSI (picsi) in sibling oocytes |
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| المؤلفون: | Iris Nefesh, Efrat Esh-Broder, Michal Novoselsky Persky, Amy Solnica, Yuval Bdolah, Mali Ketzin El Gilad, Anat Hershko-Klement, Arye Hurwitz |
| المصدر: | Andrology. 9:873-877 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, Pregnancy Rate, Urology, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Biology, Intracytoplasmic sperm injection, Andrology, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Human fertilization, Pregnancy, medicine, Humans, Sperm Injections, Intracytoplasmic, Hyaluronic Acid, reproductive and urinary physiology, Retrospective Studies, 030219 obstetrics & reproductive medicine, In vitro fertilisation, urogenital system, Embryogenesis, Embryo, Oocyte, Spermatozoa, Sperm, medicine.anatomical_structure, Reproductive Medicine, embryonic structures, Female, Embryo quality |
| الوصف: | Background Physiological selection of spermatozoa for ICSI (PICSI) is a sperm selection method based on sperm binding to hyaluronic acid. Previous studies on the effect of hyaluronic acid binding assays on fertilization and embryo quality have shown inconsistent results. Previous sibling oocyte studies have not found a significant improvement in fertilization or embryo development with hyaluronic acid binding assays. Objective To compare fertilization and embryo development between standard intracytoplasmic sperm injection (ICSI) and PICSI in sibling oocytes. Materials and methods This is a retrospective analysis of all in vitro fertilization (IVF) cycles between January 2017 and April 2020 in which sibling oocytes were randomly fertilized by both ICSI and PICSI. Fertilization rate and the rate of embryos eligible for transfer were compared. Results Forty-five IVF cycles, in which 257 oocytes were fertilized with PICSI and 294 with standard ICSI, were compared. Most of the patients included in the study had previous failures of fertilization, poor embryonic development, implantation failure, or miscarriage. All but two of the patients had at least one previous unsuccessful IVF cycle. Both fertilization rates (71% vs. 83%) and transfer eligible embryo rates (38% vs. 51%) were significantly higher in PICSI fertilized oocytes (p = 0.008 and p = 0.01 respectively). Discussion Our study is the largest sibling oocyte study comparing ICSI and PICSI, and the first to find a significant improvement in fertilization and embryo quality with PICSI using sibling oocytes. The fact our cohort included almost exclusively couples with previous unsuccessful IVF cycles might suggest that PICSI should be used in selected cases. Conclusion PICSI improves fertilization rates and transfer eligible embryo rates in sibling oocytes in a selected study group. |
| تدمد: | 2047-2927 2047-2919 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68970e7fc571e2d0f51bbd2787bee5fa https://doi.org/10.1111/andr.12982 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....68970e7fc571e2d0f51bbd2787bee5fa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20472927 20472919 |
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