Carbapenem-resistant Enterobacteriaceae in patients with bacteraemia at tertiary hospitals in South Africa, 2015 to 2018
| العنوان: | Carbapenem-resistant Enterobacteriaceae in patients with bacteraemia at tertiary hospitals in South Africa, 2015 to 2018 |
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| المؤلفون: | Andrew Whitelaw, Vindana Chibabhai, Husna Ismail, Olga Perovic, Jeannette Wadula, P Ramjathan, Vanessa Quan, Marshagne Smith, Prathna Bhola, Ashika Singh-Moodley, Colleen Bamford, Trusha Nana, for Germs-Sa, K Swe Swe-Han, Nontombi Marylucy Mbelle |
| المصدر: | European Journal of Clinical Microbiology & Infectious Diseases. 39:1287-1294 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | DNA, Bacterial, Male, 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Imipenem, 030106 microbiology, Bacteremia, Microbial Sensitivity Tests, Carbapenem-resistant enterobacteriaceae, Meropenem, beta-Lactamases, Tertiary Care Centers, South Africa, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Medical microbiology, Bacterial Proteins, Risk Factors, Internal medicine, medicine, Humans, Infection control, Blood culture, 030212 general & internal medicine, Retrospective Studies, Cross Infection, medicine.diagnostic_test, business.industry, Mortality rate, Enterobacteriaceae Infections, General Medicine, bacterial infections and mycoses, Anti-Bacterial Agents, Carbapenem-Resistant Enterobacteriaceae, Infectious Diseases, Carbapenems, chemistry, Epidemiological Monitoring, Female, business, Ertapenem, medicine.drug |
| الوصف: | Enhanced surveillance for CREs was established at national sentinel sites in South Africa. We aimed to apply an epidemiological and microbiological approach to characterise CREs and to assess trends in antimicrobial resistance from patients admitted to tertiary academic hospitals. A retrospective analysis was conducted on patients of all ages with CRE bacteraemia admitted at any one of 12 tertiary academic hospitals in four provinces (Gauteng, KwaZulu-Natal, Western Cape and Free State) in South Africa. The study period was from July 2015 to December 2018. A case of CRE bacteraemia was defined as a patient admitted to one of the selected tertiary hospitals where any of the Enterobacteriaceae was isolated from a blood culture, and was resistant to the carbapenems (ertapenem, meropenem, imipenem and/or doripenem) or had a positive result for the Modified Hodge Test (MHT) according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. A positive blood culture result obtained after 21 days of the last blood culture result was regarded as a new case. To distinguish hospital-acquired (HA) from the community-acquired (CA) bacteraemia, the following definitions were applied: the HA CRE bacteraemia was defined as a patient with CRE isolated from blood culture ≥ 72 h of hospital admission or with any prior healthcare contact, within 1 year prior to the current episode or referral from a healthcare facility where the patient was admitted before the current hospital. A case of the CA CRE bacteraemia was defined as a patient with CRE isolated from blood culture |
| تدمد: | 1435-4373 0934-9723 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6905694f80149da71331f19199324480 https://doi.org/10.1007/s10096-020-03845-4 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....6905694f80149da71331f19199324480 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14354373 09349723 |
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