Swimming training reduces glucose‐amplifying pathway and cholinergic responses in islets from lean‐ and MSG‐obese rats
| العنوان: | Swimming training reduces glucose‐amplifying pathway and cholinergic responses in islets from lean‐ and MSG‐obese rats |
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| المؤلفون: | Paulo Cezar de Freitas Mathias, Patricia Cristine Borck, Nayara C. Leite, Sabrina Grassiolli, Michael Machado, Sarah Rickli, Antonio Carlos Boschero, Jessica C. de L. Alípio, José Carlos Rebuglio Vellosa, Ana C. Valcanaia |
| المصدر: | Clinical and Experimental Pharmacology and Physiology. 47:286-293 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, endocrine system, medicine.medical_specialty, Thapsigargin, Physiology, Monosodium glutamate, Islets of Langerhans, Random Allocation, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Thinness, Physiology (medical), Internal medicine, Insulin Secretion, Sodium Glutamate, Muscarinic acetylcholine receptor, medicine, Animals, Obesity, Rats, Wistar, Swimming, computer.programming_language, Receptor, Muscarinic M3, Pharmacology, geography, geography.geographical_feature_category, Dose-Response Relationship, Drug, business.industry, sed, Pancreatic islets, Islet, Acetylcholine, Cholinergic Neurons, Rats, Glucose, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Animals, Newborn, chemistry, 030220 oncology & carcinogenesis, Cholinergic, business, computer, Signal Transduction, medicine.drug |
| الوصف: | Here, we investigate the effects of exercise training on glucose- and cholinergic-induced insulin secretion in pancreatic islets from obese and lean rats. Male Wistar rats were treated with monosodium glutamate (MSG) for the first 5 days of life, while control (CON) rats received saline. At 21 days, the rats were divided into exercised (EXE) and sedentary (SED) groups. The EXE rats swam for 30 minutes, three times/week, for 10 weeks. After this, MSG-SED rats showed hyperglycaemia, hypertriglyceridaemia and hyperinsulinaemia. Besides, islets from MSG-SED rats exhibited increased glucose-stimulated insulin secretion (GSIS), followed by impaired glucose sensitivity, absence of glucose-amplifying pathway and weak cholinergic response. In contrast, adiposity, hyperinsulinaemia and hypertriglyceridaemia were reduced in MSG-EXE rats. Moreover, islets from MSG-EXE rats exhibited lower GSIS and improved islet glucose sensitivity, without restoration of the glucose-amplifying pathway or alteration in the weak cholinergic effect of these islets. In islets from CON-EXE rats we also observed reduced GSIS and absence of glucose-amplifying effects and an accentuated reduction in cholinergic insulinotropic responses, without effect on glucose sensitivity in pancreatic islets from this group. Neither obesity nor exercise modified Muscarinic Receptor 3 (M3R) immunocontent or its downstream pathways (PKC and PKA). Moreover, only CON-EXE showed increased GSIS in the presence of calcium blocker, Thapsigargin. In conclusion, swimming training reduces GSIS and cholinergic responsiveness in isolated pancreatic islets from lean and hypothalamic obese rats, which could be due to the inhibition of glucose-amplifying pathways. |
| تدمد: | 1440-1681 0305-1870 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69465c820cb3807908a1de41c96e09ed https://doi.org/10.1111/1440-1681.13197 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....69465c820cb3807908a1de41c96e09ed |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14401681 03051870 |
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