Effectiveness and safety of Ivermectin in COVID‐19 patients: A prospective study at a safety‐net hospital
| العنوان: | Effectiveness and safety of Ivermectin in COVID‐19 patients: A prospective study at a safety‐net hospital |
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| المؤلفون: | Rodolfo Magallanes Balderas, Zulfiya Manning, Rajashree Anandakrishnan, Esad Ulker, Muhammad Effendi, Suleyman Yasin Goksu, Mohammed Mahdi, Muhammet Ozer, Reena Conception, Kim To, Marc Whitman, Manish Gugnani |
| المصدر: | Journal of Medical Virology. 94:1473-1480 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Logistic regression, law.invention, Young Adult, Ivermectin, law, Virology, Internal medicine, medicine, Humans, Intubation, Hospital Mortality, Prospective Studies, Propensity Score, Prospective cohort study, Aged, Aged, 80 and over, Mechanical ventilation, Univariate analysis, business.industry, COVID-19, Length of Stay, Middle Aged, Respiration, Artificial, Intensive care unit, COVID-19 Drug Treatment, Intensive Care Units, Logistic Models, Infectious Diseases, Propensity score matching, Female, business, Safety-net Providers, medicine.drug |
| الوصف: | BACKGROUND: Ivermectin has been found to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in vitro. It is unknown whether this inhibition of SARS-CoV-2 replication correlates with improved clinical outcomes. OBJECTIVE: To assess the effectiveness and safety of ivermectin in hospitalized patients with COVID-19. METHODS AND MATERIALS: A total of 286 patients with COVID-19 were included in the study. Univariate analysis of the primary mortality outcome and comparisons between treatment groups were determined. Logistic regression and propensity score matching (PSM) was used to adjust for confounders. RESULTS: Patients in the ivermectin group received 2 doses of ivermectin at 200 µg/kg in addition to usual clinical care on hospital days 1 and 3. The ivermectin group had a significantly higher length of hospital stay than the control group; however, this significance did not maintain on multivariable logistic regression analysis. The length of ICU stay and duration of mechanical ventilation were longer in the control group. However, a mortality benefit was not seen with ivermectin treatment before and after PSM (p values = 0.07 and 0.11, respectively). Intensive care unit (ICU) admission, and intubation rate were not significantly different between the groups (p=0.49, and p=1.0, respectively). CONCLUSION: No differences were found between groups regarding the length of hospital stay, ICU admission, intubation rate, and in-hospital mortality. This article is protected by copyright. All rights reserved. |
| تدمد: | 1096-9071 0146-6615 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696bcfcbd20a2363b72072cad5150f58 https://doi.org/10.1002/jmv.27469 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....696bcfcbd20a2363b72072cad5150f58 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10969071 01466615 |
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