Pancreatic stone protein as a novel marker for neonatal sepsis
| العنوان: | Pancreatic stone protein as a novel marker for neonatal sepsis |
|---|---|
| المؤلفون: | Rolf Graf, Andreas Woerner, Urs Zimmermann-Baer, D Glauser, Luregn J. Schlapbach, Mathias Nelle, Martin Stocker, Mark Alan Fontana, Thierry Roger, Eric Giannoni, C Mueller |
| المساهمون: | University of Zurich, Schlapbach, Luregn J |
| المصدر: | Schlapbach, Luregn J; Graf, Rolf; Woerner, Andreas; Fontana, Matteo; Zimmermann-Baer, Urs; Glauser, David; Giannoni, Eric; Roger, Thierry; Müller, Christoph; Nelle, Mathias; Stocker, Martin (2013). Pancreatic stone protein as a novel marker for neonatal sepsis. Intensive care medicine, 39(4), pp. 754-63. Berlin: Springer-Verlag 10.1007/s00134-012-2798-3 <http://dx.doi.org/10.1007/s00134-012-2798-3> Intensive care medicine Critical Care |
| بيانات النشر: | Springer-Verlag, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Pathology, Neonatal intensive care unit, Critical Care and Intensive Care Medicine, Gastroenterology, Procalcitonin, 0302 clinical medicine, Lithostathine, 030212 general & internal medicine, Prospective Studies, Receptors, Immunologic, Prospective cohort study, Membrane Glycoproteins, biology, Neonatal sepsis, Area under the curve, Migration Inhibitory Factor, 3. Good health, C-Reactive Protein, Biomarker (medicine), Pancreatic stone protein, Female, 2706 Critical Care and Intensive Care Medicine, Switzerland, Calcitonin, medicine.medical_specialty, Calcitonin Gene-Related Peptide, 610 Medicine & health, Sepsis, 03 medical and health sciences, 030225 pediatrics, Internal medicine, Intensive Care Units, Neonatal, medicine, Humans, Protein Precursors, Macrophage Migration-Inhibitory Factors, 10217 Clinic for Visceral and Transplantation Surgery, business.industry, C-reactive protein, Infant, Newborn, Diagnostic marker, medicine.disease, Triggering Receptor Expressed on Myeloid Cells-1, eye diseases, 10022 Division of Surgical Research, ROC Curve, Poster Presentation, biology.protein, 570 Life sciences, business, Biomarkers |
| الوصف: | Purpose: Early-onset sepsis (EOS) is one of the main causes for the admission of newborns to the neonatal intensive care unit. However, traditional infection markers are poor diagnostic markers of EOS. Pancreatic stone protein (PSP) is a promising sepsis marker in adults. The aim of this study was to investigate whether determining PSP improves the diagnosis of EOS in comparison with other infection markers. Methods: This was a prospective multicentre study involving 137 infants with a gestational age of >34weeks who were admitted with suspected EOS. PSP, procalcitonin (PCT), soluble human triggering receptor expressed on myeloid cells-1 (sTREM-1), macrophage migration inhibitory factor (MIF) and C-reactive protein (CRP) were measured at admission. Receiver-operating characteristic (ROC) curve analysis was performed. Results: The level of PSP in infected infants was significantly higher than that in uninfected ones (median 11.3 vs. 7.5ng/ml, respectively; p=0.001). The ROC area under the curve was 0.69 [95% confidence interval (CI) 0.59-0.80; p9ng/ml) and PCT (>2ng/ml) was the best predictor of EOS (0.83; 95% CI 0.74-0.93; p |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697548b5ba4ddba2f5b716e454816957 https://boris.unibe.ch/16553/1/134_2012_Article_2798.pdf |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....697548b5ba4ddba2f5b716e454816957 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |