Pharmaceutical Significance of the Stereoisomerisation Process
| العنوان: | Pharmaceutical Significance of the Stereoisomerisation Process |
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| المؤلفون: | Lucija Hok, Davor Šakić, Valerije Vrček, Robert Vianello |
| المصدر: | Kemija u industriji : časopis kemičara i tehnologa Hrvatske Kemija u industriji : Časopis kemičara i kemijskih inženjera Hrvatske Volume 72 Issue 1-2 |
| بيانات النشر: | Hrvatsko društvo kemijskih inženjera i tehnologa, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | stereoizomeri, konfiguracijska nestabilnost, farmakološka i farmaceutska vremenska skala, kiralni lijekovi, Chemistry, General Chemical Engineering, stereoisomers, configurational instability, pharmacological and pharmaceutical time scales, chiral drugs, General Chemistry, Pharmacy |
| الوصف: | Proučavanje procesa stereoizomerizacije od iznimne je važnosti u farmaceutskoj kemiji i biomedicini. Različiti izomeri mogu pokazivati značajne razlike u interakciji s biološkim makromolekulama, što može dovesti do razlika i u njihovim farmakokinetičkim i farmakodinamičkim svojstvima te, u konačnici, u terapijskim i neželjenim učincima. Iako postoji velik broj primjera koji svjedoče o važnosti stereokemije, u ovome radu dan je pregled nekoliko najznačajnijih i najreprezentativnijih slučajeva u farmaciji. Investigation of the stereoisomerisation process is of the utmost importance in pharmaceutical chemistry and biomedicine. Different isomers can exhibit significant differences when interacting with biological macromolecules, which may result in their modified pharmacokinetic and pharmacodynamic properties, thereby showing different therapeutic and undesirable effects. Although there are numerous examples illustrating the importance of stereochemistry, this article presents an overview of the most significant and representative cases in pharmacy. |
| وصف الملف: | application/pdf |
| اللغة: | Croatian |
| تدمد: | 0022-9830 1334-9090 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698ab1fba0423ee5e94edeeb10296813 http://fulir.irb.hr/7993/1/1245962.6-55-64-KUI-1-2-2023.pdf |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....698ab1fba0423ee5e94edeeb10296813 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00229830 13349090 |
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