Big gamma-glutamyltransferase is associated with epicardial fat volume and cardiovascular outcome in the general population
| العنوان: | Big gamma-glutamyltransferase is associated with epicardial fat volume and cardiovascular outcome in the general population |
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| المؤلفون: | Alberto Aimo, Sara Chiappino, Aldo Paolicchi, Daniele Della Latta, Nicola Martini, Alberto Clemente, Veronica Musetti, Silvia Masotti, Giorgia Panichella, Valeria Piagneri, Simona Storti, Angelo Monteleone, Claudio Passino, Dante Chiappino, Maria Franzini, Michele Emdin |
| المصدر: | European Journal of Preventive Cardiology. 29:1510-1518 |
| بيانات النشر: | Oxford University Press (OUP), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Epidemiology, Cardiology and Cardiovascular Medicine, digestive system, digestive system diseases |
| الوصف: | Aims Gamma-glutamyltransferase (GGT) has been recognized as a cardiovascular risk factor, and its highest molecular weight fraction [big GGT (b-GGT)] is found in vulnerable atherosclerotic plaques. We explored the relationship between b-GGT, computed tomography findings, and long-term outcomes in the general population. Methods and results Between May 2010 and October 2011, subjects aged 45–75 years living in a Tuscan city and without known cardiac disease were screened. The primary endpoint was a composite of cardiovascular death or acute coronary syndrome requiring urgent coronary revascularization. Gamma-glutamyltransferase fractions were available in 898 subjects [median age 65 years (25th–75th percentile 55–70), 46% men]. Median plasma GGT was 20 IU (15–29), and b-GGT was 2.28 (1.28–4.17). Coronary artery calcium (CAC) score values were 0 (0–60), and the volume of pro-atherogenic epicardial fat was 155 mL (114–204). In a model including age, sex, low-density lipoprotein (LDL) cholesterol, current or previous smoking status, hypertension, diabetes, obesity, b-GGT independently predicted epicardial fat volume (EFV) (r = 0.162, P < 0.001), but not CAC (P = 0.198). Over a 10.3-year follow-up (9.6–10.8), 27 subjects (3%) experienced the primary endpoint. We evaluated couples of variables including b-GGT and a cardiovascular risk factor, CAC or EFV. Big GGT yielded independent prognostic significance from age, LDL cholesterol, current or previous smoking status, hypertension, diabetes, obesity, but not CAC or EFV. Conversely, GGT predicted the primary endpoint even independently from CAC and EFV. Conclusion Big GGT seemed at least as predictive as the commonly available GGT assay; therefore, the need for b-GGT rather than GGT measurement should be carefully examined. |
| تدمد: | 2047-4881 2047-4873 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699227fe0a761a6c3d8e9ffcaceedcd7 https://doi.org/10.1093/eurjpc/zwab215 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....699227fe0a761a6c3d8e9ffcaceedcd7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20474881 20474873 |
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