Incidence of hypothyroidism after treatment for breast cancer-a Danish matched cohort study
| العنوان: | Incidence of hypothyroidism after treatment for breast cancer-a Danish matched cohort study |
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| المؤلفون: | Jeanette Dupont Jensen, Kristin V. Reinertsen, Marianne Ewertz, Anne Mette Falstie-Jensen, Buket Öztürk Esen, Olaf M. Dekkers, Deirdre Cronin-Fenton, Ebbe Laugaard Lorenzen, Anders Kjærsgaard |
| المصدر: | Falstie-Jensen, A M, Esen, B Ö, Kjærsgaard, A, Lorenzen, E L, Jensen, J D, Reinertsen, K V, Dekkers, O M, Ewertz, M & Cronin-Fenton, D P 2020, ' Incidence of hypothyroidism after treatment for breast cancer-a Danish matched cohort study ', Breast cancer research : BCR, vol. 22, no. 1, pp. 106 . https://doi.org/10.1186/s13058-020-01337-z Falstie-Jensen, A M, Esen, B, Kjærsgaard, A, Lorenzen, E L, Jensen, J D, Reinertsen, K V, Dekkers, O M, Ewertz, M & Cronin-Fenton, D P 2020, ' Incidence of hypothyroidism after treatment for breast cancer-a Danish matched cohort study ', Breast Cancer Research, vol. 22, no. 1, 106 . https://doi.org/10.1186/s13058-020-01337-z Falstie-Jensen, A M, Esen, B, Kjærsgaard, A, Lorenzen, E L, Jensen, J D, Reinertsen, K V, Dekkers, O M, Ewertz, M & Cronin-Fenton, D P 2020, ' Incidence of hypothyroidism after treatment for breast cancer—a Danish matched cohort study ', Breast Cancer Research, vol. 22, 106 . https://doi.org/10.1186/s13058-020-01337-z Breast Cancer Research : BCR Breast Cancer Research, Vol 22, Iss 1, Pp 1-10 (2020) Breast Cancer Research, 22(1). BMC |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Breast Neoplasms/pathology, Carcinoma, Ductal, Breast/pathology, medicine.medical_treatment, Denmark, Cohort Studies, 0302 clinical medicine, Breast cancer, Antineoplastic Combined Chemotherapy Protocols, Radiotherapy, Adjuvant/adverse effects, Cumulative incidence, 030212 general & internal medicine, Matched cohort study, Aged, 80 and over, Incidence (epidemiology), Thyroid disease, Incidence, Hazard ratio, Carcinoma, Ductal, Breast, Absolute risk reduction, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Radiation therapy, 030220 oncology & carcinogenesis, Female, medicine.drug, Research Article, Adult, medicine.medical_specialty, Cancer survivorship, Levothyroxine, Breast Neoplasms, lcsh:RC254-282, 03 medical and health sciences, Hypothyroidism, Internal medicine, medicine, Chemotherapy, Humans, Aged, business.industry, Antineoplastic Combined Chemotherapy Protocols/adverse effects, medicine.disease, Denmark/epidemiology, Hypothyroidism/epidemiology, Late effect, Case-Control Studies, Lymph Nodes/pathology, Radiotherapy, Adjuvant, Lymph Nodes, business |
| الوصف: | Background Breast cancer survivors (BCS) may have increased risk of hypothyroidism, but risk according to treatment modality is unclear. We estimated the incidence of hypothyroidism in women with breast cancer, and according to cancer treatment. Methods Using nationwide registries, we identified all Danish women aged ≥ 35 years diagnosed with non-metastatic breast cancer (1996–2009). We matched up to five cancer-free women (controls) for each BCS. We excluded women with prevalent thyroid disease. Cancer treatment was chemotherapy with or without radiotherapy (RT) targeting the breast/chest wall only, or also the lymph nodes (RTn). We identified hypothyroidism using diagnostic codes, and/or levothyroxine prescriptions. We calculated the cumulative incidence, incidence rates (IR) per 1000 person-years, and used Cox regression to estimate hazard ratios (HR) and associated 95% confidence intervals (CIs) of hypothyroidism, adjusting for comorbidities. Results We included 44,574 BCS and 203,306 matched controls with 2,631,488 person-years of follow-up. BCS had a slightly higher incidence of hypothyroidism than controls [5-year cumulative incidence, 1.8% (95%CI = 1.7–1.9) and 1.6% (95%CI = 1.5–1.6), respectively]. The overall IR was 4.45 (95%CI = 4.25–4.67) and 3.81 (95%CI = 3.73–3.90), corresponding to an adjusted HR = 1.17 (95%CI = 1.11–1.24). BCS who received RTn with chemotherapy (HR = 1.74, 95%CI = 1.50–2.02) or without chemotherapy (HR = 1.31, 95%CI = 1.14–1.51) had an elevated risk of hypothyroidism compared with matched controls and compared with BCS who underwent surgery alone [HR = 1.71, 95%CI = 1.45–2.01 and HR = 1.36, 95%CI = 1.17–1.58, respectively]. Conclusions BCS have an excess risk of hypothyroidism compared with age-matched controls. BCS and those working in cancer survivorship settings ought to be aware that this risk is highest in women treated with radiation therapy to the lymph nodes and chemotherapy. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e13ec32d63198d6a821a8aaef8a564 https://pure.au.dk/portal/da/publications/incidence-of-hypothyroidism-after-treatment-for-breast-cancera-danish-matched-cohort-study(f5a80ae0-07fb-4467-a194-290a4c5369d0).html |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....69e13ec32d63198d6a821a8aaef8a564 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |