A Comparison of Intranasal Dexmedetomidine and Dexmedetomidine Plus Buccal Midazolam for Non-painful Procedural Sedation in Children with Autism
| العنوان: | A Comparison of Intranasal Dexmedetomidine and Dexmedetomidine Plus Buccal Midazolam for Non-painful Procedural Sedation in Children with Autism |
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| المؤلفون: | Na Zhang, V. M. Yuen, Bi Lian Li, Jun Xiang Huang, Si Yuan Yang, Jeffery W. Miller, Huan Huan Zhang, Xing Rong Song |
| المصدر: | Journal of Autism and Developmental Disorders. 49:3798-3806 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Midazolam, Sedation, 03 medical and health sciences, 0302 clinical medicine, Primary outcome, Double-Blind Method, mental disorders, Developmental and Educational Psychology, medicine, Humans, Hypnotics and Sedatives, 0501 psychology and cognitive sciences, Autistic Disorder, Dexmedetomidine, Child, Administration, Intranasal, 05 social sciences, Administration, Buccal, Buccal administration, medicine.disease, Auditory brainstem response, Child, Preschool, Anesthesia, Autism, Drug Therapy, Combination, Female, Nasal administration, medicine.symptom, Psychology, 030217 neurology & neurosurgery, 050104 developmental & child psychology, medicine.drug |
| الوصف: | Children with autism often need sedation for diagnostic procedures and they are often difficult to sedate. This prospective randomized double-blind control trial evaluates the efficacy and safety using intranasal dexmedetomidine with and without buccal midazolam for sedation in children with autism undergoing computerized tomography and/or auditory brainstem response test. The primary outcome is the proportion of children attaining satisfactory sedation. One hundred and thirty-six children received intranasal dexmedetomidine and 139 received intranasal dexmedetomidine with buccal midazolam for sedation. Combination of intranasal dexmedetomidine and buccal midazolam was associated with higher sedation success when compared to intranasal dexmedetomidine. Since intranasal and buccal sedatives required little cooperation this could be especially useful technique for children with autism or other behavioral conditions. |
| تدمد: | 1573-3432 0162-3257 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e3f71e108d3707698df379ebd6eaff https://doi.org/10.1007/s10803-019-04095-w |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....69e3f71e108d3707698df379ebd6eaff |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15733432 01623257 |
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