Patients younger than 70 undergoing transcatheter aortic valve implantation: Procedural outcomes and mid-term survival
| العنوان: | Patients younger than 70 undergoing transcatheter aortic valve implantation: Procedural outcomes and mid-term survival |
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| المؤلفون: | Eustachio Agricola, Caterina Mula, Marco Ancona, Barbara Bellini, Filippo Russo, Igor Belluschi, Vittorio Romano, Nicola Buzzatti, Matteo Montorfano, Antonio Sorropago, Francesco Moroni, Alessandro Beneduce, Evelina Toscano, Costanza Festorazzi, Marco Gamardella, Luca A. Ferri, Ciro Vella |
| المساهمون: | Ancona, Marco B, Toscano, Evelina, Moroni, Francesco, Ferri, Luca A, Russo, Filippo, Bellini, Barbara, Sorropago, Antonio, Mula, Caterina, Festorazzi, Costanza, Gamardella, Marco, Vella, Ciro, Beneduce, Alessandro, Romano, Vittorio, Belluschi, Igor, Buzzatti, Nicola, Agricola, Eustachio, Montorfano, Matteo |
| المصدر: | International Journal of Cardiology: Heart & Vasculature, Vol 34, Iss, Pp 100817-(2021) International Journal of Cardiology. Heart & Vasculature |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Transcatheter aortic, Long term durability, medicine.medical_treatment, THV, transcatheter heart valve, Population, 030204 cardiovascular system & hematology, SAVR, surgical aortic valve replacement, Prosthesis, 03 medical and health sciences, Liver disease, BEV, balloon expandable valve, 0302 clinical medicine, Medicine, Diseases of the circulatory (Cardiovascular) system, 030212 general & internal medicine, education, Transcatheter heart valve, education.field_of_study, Original Paper, Transcatheter aortic valve implantation, business.industry, CABG, coronary artery bypass graft, High risk, Incidence (epidemiology), Aortic stenosis, SEV, self expandable valve, Retrospective cohort study, medicine.disease, Surgery, Stenosis, Young population, RC666-701, TAVI, transcatheter aortic valve implantation, Cardiology and Cardiovascular Medicine, business |
| الوصف: | Introduction Based on recent data, the indication for transcatheter aortic valve implantation (TAVI) is expanding to individuals at lower surgical risk, who are generally younger than subjects historically treated for severe aortic stenosis. Indeed, younger patients have traditionally been under-represented in current TAVI literature. The aim of the present study is to report about clinical features, procedural outcomes and mid-term outcomes of patients younger than 70 who underwent TAVI in a single high-volume center. Materials and methods Consecutive patients younger than 70 years of age who underwent TAVI for severe, symptomatic aortic stenosis between 2007 and 2019 at a single, tertiary referral center have been included in this retrospective study. Procedural and mid-term outcomes were analyzed, comparing 1st generation with 2nd generation devices. Results Between 2007 and 2019, 1740 TAVI procedures were performed in our center. Among these, one hundred twenty-nine (7.4%) patients were younger than 70 years at the time of the intervention and were included in the present analysis. Fifty-eight patients (45%) were implanted with a 1st generation prosthesis while seventy-one patients (55%) were implanted with a 2nd generation device. Reasons which lead to a transcatheter approach in this population were: previous CABG (27.9%); porcelain aorta (24%); severe left ventricular systolic dysfunction (21.7%); prior chest radiation (19.4%); severe lung disease (8.5%); hemodynamic instability (7.0%); advanced liver disease (4.6%) and active cancer (3.9%). Overall device success rate was 89%, with no differences among 1st and 2nd generation devices. Threeyears all-cause mortality was 34%, with no difference among the two groups. Low incidence of aortic-valve re-intervention was observed at mid-term follow-up (late valve re-intervention = 2.3%). Conclusions TAVI in young patient with appropriate indication for intervention is a safe procedure, associated with low rate of in hospital mortality and low rate of severe complications both with 1st and with 2nd generation devices. When considering long term durability, more data are needed; in our case series long-term follow up shows a good survival and also an extremely low rate of valve re-intervention. |
| اللغة: | English |
| تدمد: | 2352-9067 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e4b7cf0d3ecdf9581334a01bf1aa38 http://www.sciencedirect.com/science/article/pii/S2352906721001056 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....69e4b7cf0d3ecdf9581334a01bf1aa38 |
| قاعدة البيانات: | OpenAIRE |
Full Text via ClinicalKey | تدمد: | 23529067 |
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