Discovery of a Novel G-Quadruplex and Histone Deacetylase (HDAC) Dual-Targeting Agent for the Treatment of Triple-Negative Breast Cancer
| العنوان: | Discovery of a Novel G-Quadruplex and Histone Deacetylase (HDAC) Dual-Targeting Agent for the Treatment of Triple-Negative Breast Cancer |
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| المؤلفون: | Xin-Chen Jiang, Fang-Hai Tu, Li-Yuan Wei, Bo-Zheng Wang, Hao Yuan, Jing-Mei Yuan, Yong Rao, Shi-Liang Huang, Qing-Jiang Li, Tian-Miao Ou, Hong-Gen Wang, Jia-Heng Tan, Shuo-Bin Chen, Zhi-Shu Huang |
| المصدر: | Journal of Medicinal Chemistry. 65:12346-12366 |
| بيانات النشر: | American Chemical Society (ACS), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Histone Deacetylase Inhibitors, Zinc, Cell Line, Tumor, Drug Discovery, Humans, Molecular Medicine, Antineoplastic Agents, Apoptosis, Triple Negative Breast Neoplasms, DNA, Xenograft Model Antitumor Assays, Histone Deacetylases, Cell Proliferation |
| الوصف: | The development of triple-negative breast cancer (TNBC) is highly associated with G-quadruplex (G4); thus, targeting G4 is a potential strategy for TNBC therapy. Because concomitant histone deacetylases (HDAC) inhibition could amplify the impact of G4-targeting compounds, we designed and synthesized two novel series of G4/HDAC dual-targeting compounds by connecting the zinc-binding pharmacophore of HDAC inhibitors to the G4-targeting isaindigotone scaffold ( |
| تدمد: | 1520-4804 0022-2623 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ee936cf4c88cd1bc4652ea3f6093fb https://doi.org/10.1021/acs.jmedchem.2c01058 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....69ee936cf4c88cd1bc4652ea3f6093fb |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15204804 00222623 |
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