Effect of Imipramine on radiosensitivity of Prostate Cancer: An In Vitro Study
| العنوان: | Effect of Imipramine on radiosensitivity of Prostate Cancer: An In Vitro Study |
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| المؤلفون: | Songül Barlaz Us, Serap Yalin, Şakir Necat Yılmaz, Metin Yildirim, Ulku Comelekoglu, Fatma Sogut, Derya Yetkin |
| المصدر: | Cancer Investigation. 37:489-500 |
| بيانات النشر: | Informa UK Limited, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Imipramine, Radiation-Sensitizing Agents, Cancer Research, Cell cycle checkpoint, Cell Survival, medicine.medical_treatment, Down-Regulation, urologic and male genital diseases, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, DU145, Cell Line, Tumor, medicine, Humans, Radiosensitivity, Cell Proliferation, Radiotherapy, business.industry, Cell Cycle, Prostatic Neoplasms, Cancer, General Medicine, medicine.disease, Ether-A-Go-Go Potassium Channels, Gene Expression Regulation, Neoplastic, Radiation therapy, Oxidative Stress, 030104 developmental biology, Oncology, Apoptosis, 030220 oncology & carcinogenesis, Cancer research, business, medicine.drug |
| الوصف: | Prostate cancer is the most common cancer and leading cause of cancer death for males. Imipramine (IMI), which is a tricyclic antidepressant, has also been shown to has antineoplastic effect. This study was performed to investigate the radiosensitizing effect of IMI on DU145 prostate cancer cell. Cells were divided into 4 groups. Cell index, apoptotic activity, cell cycle arrest, oxidative stress and EAG1 channel currents were determined in all groups. Our findings showed that combined treatment with IMI and radiotherapy (RAD) did not enhance radiosensitivity of DU145 cells but as unexpected finding, treatment of IMI alone was more effective in DU145 cells. |
| تدمد: | 1532-4192 0735-7907 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2bae0859061297811671840c6649b6 https://doi.org/10.1080/07357907.2019.1662434 |
| رقم الأكسشن: | edsair.doi.dedup.....6a2bae0859061297811671840c6649b6 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 15324192 07357907 |
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