O,O,S-Trimethyl phosphorothioate induces hypothermia in Fischer 344 rats in a manner dependent on both doses and housing temperatures
| العنوان: | O,O,S-Trimethyl phosphorothioate induces hypothermia in Fischer 344 rats in a manner dependent on both doses and housing temperatures |
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| المؤلفون: | Yi-He Jin, Mikako Tsukada, Akio Koizumi, Yasuhiko Wada, Naoto Hamade |
| المصدر: | Archives of Toxicology. 67:72-75 |
| بيانات النشر: | Springer Science and Business Media LLC, 1993. |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | medicine.medical_specialty, Health, Toxicology and Mutagenesis, Pharmacology toxicology, Hypothermia, Toxicology, Body Temperature, Lethal Dose 50, Internal medicine, Hypophagia, medicine, Animals, Delayed toxicity, Chemistry, Organothiophosphates, Temperature, General Medicine, Thermoregulation, Special class, Rats, Inbred F344, Rats, Surgery, Endocrinology, Toxicity, Female, medicine.symptom |
| الوصف: | We explored the effects of O,O,S-trimethyl phosphorothioate (OOS-TMP) on body temperatures in Fischer 344 female rats. The 7-day LD50 p.o. for Fischer 344 female rats was found to be 11.8 mg/kg. OOS-TMP induced long-lasting (more than 48 h) and extensive hypothermia at dosesor = 14 mg/kg at a typical laboratory temperature (22 degrees C) while it produced typical symptoms at 10 mg/kg without hypothermia. In contrast, pair-fed (to 20 mg/kg rats) rats (n = 4) did not become hypothermic, negating any role of hypophagia in OOS-TMP associated hypothermia. We next investigated the effects of housing temperatures on toxicities at a LD50 dose (12 mg/kg). At 30 degrees C (n = 11) and 22 degrees C (n = 13), rats did not have hypothermic bouts but at 15 degrees C, eight out of ten rats had. Evidence that changes of housing temperatures neither modified clinical symptoms nor changed mortality rates discards a possibility of hypothermia being involved in delayed toxicity. A novel result of the present study suggests that thermoregulation may be heavily impaired by a special class of organophosphorus compounds. |
| تدمد: | 1432-0738 0340-5761 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a979fc5295d4fbeece9bf386b96bf25 https://doi.org/10.1007/bf02072039 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....6a979fc5295d4fbeece9bf386b96bf25 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14320738 03405761 |
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