Polysaccharide conformations measured by solution state x-ray scattering
| العنوان: | Polysaccharide conformations measured by solution state x-ray scattering |
|---|---|
| المؤلفون: | Leif Lundin, Hsin-Lung Chen, Bradley W. Mansel, Timothy M. Ryan, Martin A. K. Williams |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Diffraction, Materials science, General Physics and Astronomy, FOS: Physical sciences, 02 engineering and technology, Condensed Matter - Soft Condensed Matter, 010402 general chemistry, Polysaccharide, 01 natural sciences, law.invention, chemistry.chemical_compound, law, Physical and Theoretical Chemistry, chemistry.chemical_classification, Small-angle X-ray scattering, Scattering, X-ray, Polymer, 021001 nanoscience & nanotechnology, Synchrotron, 0104 chemical sciences, Crystallography, Monomer, chemistry, Soft Condensed Matter (cond-mat.soft), 0210 nano-technology |
| الوصف: | Polysaccharides are semi-flexible polymers composed of sugar residues with a myriad of important functions including structural support, energy storage and immunogenicity. The local conformation of such chains is a crucial factor governing their interactions, where the relative orientation of adjacent sugar rings determines the propensity for hydrogen bonding and specific ion-mediated interactions with neighbouring chains. Traditionally this conformation has only been directly accessible in the solid-state, using crystallographic techniques such as fibre diffraction. Herein it is demonstrated that improvements in the quality of synchrotron-based x-ray scattering data means that conformation-dependent features, the positions of which are related to the linear repeating distance between single saccharide monomers, can now be measured in solution. This technique is expected to be universally applicable for polysaccharides that consist of comparatively stiff glycosidic linkages, and to have extensive relevance for a number of biological macromolecules, including glycosylated proteins. 11 pages, 6 figures total, including Supplemental Material on pages 6-11 |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aeadf69affe83996ac30a25f5254ca0 http://arxiv.org/abs/1909.01673 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6aeadf69affe83996ac30a25f5254ca0 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |