A retrospective study on chemical and radioactive synovectomy in severe haemophilia patients with recurrent haemarthrosis
| العنوان: | A retrospective study on chemical and radioactive synovectomy in severe haemophilia patients with recurrent haemarthrosis |
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| المؤلفون: | N. Ounnoughène, P. Verrier, Y. Sultan, D. Vassilieff, P. Molho, C.-J. Menkes, J.-M. Schacher, N. Stieltjes |
| المصدر: | Haemophilia. 5:115-123 |
| بيانات النشر: | Wiley, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Triamcinolone acetonide, Adolescent, Osmium Tetroxide, medicine.medical_treatment, Synovectomy, Hemophilia A, Haemophilia, Injections, Intra-Articular, Von willebrand, Recurrence, Hemarthrosis, medicine, Humans, Yttrium Radioisotopes, In patient, Child, Genetics (clinical), Retrospective Studies, Radioisotopes, Haemophilic arthropathy, business.industry, Retrospective cohort study, Hematology, General Medicine, Middle Aged, medicine.disease, Surgery, Child, Preschool, Radiological weapon, Radiopharmaceuticals, business, medicine.drug |
| الوصف: | Between 1970 and 1994, 116 chemical and 90 radioactive synovectomies were performed in 107 patients with severe haemophilia and two with type 3 von Willebrand's disease. The products used were osmic acid (OA) in 100 cases, 90-Yttrium in 35 cases, 186-Rhenium in 48, 169-Erbium in two, hexacetonide triamcinolone in 16 and radioactive gold in five cases. The use of radioactive colloids is not allowed in France in patients under 15 years of age. Twenty-nine patients had more than one synovectomy per joint. All patients were evaluated for 6 months post-synovectomy, using both a clinical and a radiological score. Six months after synovectomy, a good or excellent result was obtained for 81% of the joints treated with isotopes, compared with 44% of those treated with OA, P < 0.001. This superiority of isotopes over osmic acid was still observed after 6 months for the 89 joints that were re-evaluated, with follow-up ranging from 1 to 9 years. It was possible to calculate a radiological score in 84 cases. With OA the best results were from the joints with the lowest scores pre-synovectomy ( |
| تدمد: | 1365-2516 1351-8216 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af91ca5a4a5b286087b9c21f2c7eb42 https://doi.org/10.1046/j.1365-2516.1999.00287.x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....6af91ca5a4a5b286087b9c21f2c7eb42 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652516 13518216 |
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