Anti-Inflammatory Effects of Water Chestnut Extract on Cytokine Responses via Nuclear Factor-κB-signaling Pathway
| العنوان: | Anti-Inflammatory Effects of Water Chestnut Extract on Cytokine Responses via Nuclear Factor-κB-signaling Pathway |
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| المؤلفون: | Hyun Soo Kim, Jin Eun Kim, Bora Kim, Byung Kook Choi |
| المصدر: | Biomolecules & Therapeutics |
| بيانات النشر: | The Korean Society of Applied Pharmacology, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Skin erythema, Lipopolysaccharide, medicine.drug_class, medicine.medical_treatment, Pharmacology, Biochemistry, Anti-inflammatory, Nitric oxide, chemistry.chemical_compound, Drug Discovery, medicine, Cytokine, chemistry.chemical_classification, Reactive oxygen species, biology, business.industry, Anti-inflammatory effect, NF-αB, Water chestnut, Trapa japonica Flerov, Nitric oxide synthase, chemistry, Immunology, biology.protein, Molecular Medicine, Original Article, Cytokine secretion, business |
| الوصف: | Water chestnut (Trapa japonica Flerov.) is an annual aquatic plant. In the present study, we showed that the treatment of water chestnut extracted with boiling water resulted in a significant increase 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging activity and decrease the intracellular H2O2-induced accumulation of reactive oxygen species. In addition, water chestnut extract (WCE) inhibited lipopolysaccharide (LPS)-induced nitric oxide production and suppressed mRNA and protein expression of the inducible nitric oxide synthase gene. The cytokine array results showed that WCE inhibited inflammatory cytokine secretion. Also, WCE reduced tumor necrosis factor-α-and interleukin-6-induced nuclear factor-αB activity. Furthermore, during sodium lauryl sulfate (SLS)-induced irritation of human skin, WCE reduced SLS-induced skin erythema and improved barrier regeneration. These results indicate that WCE may be a promising topical anti-inflammatory agent. |
| تدمد: | 1976-9148 2005-4483 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9627d3169720c6de0c6198258c02b9 https://doi.org/10.4062/biomolther.2014.080 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6b9627d3169720c6de0c6198258c02b9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19769148 20054483 |
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