Ergosta-7,9(11),22-trien-3β-ol Rescues AD Deficits by Modulating Microglia Activation but Not Oxidative Stress
| العنوان: | Ergosta-7,9(11),22-trien-3β-ol Rescues AD Deficits by Modulating Microglia Activation but Not Oxidative Stress |
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| المؤلفون: | Li-Wen Su, Wei-Yong Lin, Meng-Shiun Chang, Hsin-Ping Liu, Tsai-Ni Chuang, Yueh-Hsiung Kuo, Li-Zhong Chang, Jack Cheng |
| المصدر: | Molecules Volume 26 Issue 17 Molecules, Vol 26, Iss 5338, p 5338 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Amyloid, Pharmaceutical Science, Inflammation, Disease, Pharmacology, medicine.disease_cause, Article, Analytical Chemistry, Lipid peroxidation, chemistry.chemical_compound, QD241-441, Alzheimer Disease, Drug Discovery, medicine, Animals, Humans, Physical and Theoretical Chemistry, Antrodia, Amyloid beta-Peptides, Microglia, biology, business.industry, Organic Chemistry, biology.organism_classification, Disease Models, Animal, Neuroprotective Agents, Drosophila, medicine.anatomical_structure, chemistry, Chemistry (miscellaneous), Catalase, biology.protein, Molecular Medicine, ergosta-7,9(11),22-trien-3β-ol, medicine.symptom, Polyporales, business, Alzheimer’s disease, Oxidative stress, EK100 |
| الوصف: | Ergosta-7,9(11),22-trien-3β-ol (EK100) was isolated from the Taiwan-specific medicinal fungus Antrodia camphorata, which is known for its health-promotion and anti-aging effects in folk medicine. Alzheimer’s disease (AD) is a major aging-associated disease. We investigated the efficacy and potential mechanism of ergosta-7,9(11),22-trien-3β-ol for AD symptoms. Drosophila with the pan-neuronal overexpression of human amyloid-β (Aβ) was used as the AD model. We compared the life span, motor function, learning, memory, oxidative stress, and biomarkers of microglia activation and inflammation of the ergosta-7,9(11),22-trien-3β-ol-treated group to those of the untreated control. Ergosta-7,9(11),22-trien-3β-ol treatment effectively improved the life span, motor function, learning, and memory of the AD model compared to the untreated control. Biomarkers of microglia activation and inflammation were reduced, while the ubiquitous lipid peroxidation, catalase activity, and superoxide dismutase activity remained unchanged. In conclusion, ergosta-7,9(11),22-trien-3β-ol rescues AD deficits by modulating microglia activation but not oxidative stress. |
| وصف الملف: | application/pdf |
| تدمد: | 1420-3049 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bbc35399c2956ac4c7c49fc45c35349 https://doi.org/10.3390/molecules26175338 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6bbc35399c2956ac4c7c49fc45c35349 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14203049 |
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