The effects of dietary nitrate on plasma glucose and insulin sensitivity in sheep
| العنوان: | The effects of dietary nitrate on plasma glucose and insulin sensitivity in sheep |
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| المؤلفون: | Ian Godwin, Roger Hegarty, Maria Laura Villar, Katherine Anne Smith, Jonathon William Clay, R. C. Dobos, John Nolan |
| المصدر: | Journal of Animal Physiology and Animal Nutrition. 103:1657-1662 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Blood Glucose, inorganic chemicals, medicine.medical_specialty, 040301 veterinary sciences, Glucose uptake, medicine.medical_treatment, Nitric oxide, 0403 veterinary science, chemistry.chemical_compound, Food Animals, Internal medicine, medicine, Animals, Urea, Nitrite, Nitrites, Glucose tolerance test, Nitrates, Sheep, medicine.diagnostic_test, Insulin, 0402 animal and dairy science, food and beverages, 04 agricultural and veterinary sciences, Metabolism, Animal Feed, 040201 dairy & animal science, Diet, Endocrinology, chemistry, Basal (medicine), Dietary Supplements, Animal Nutritional Physiological Phenomena, Animal Science and Zoology, Insulin Resistance, Methemoglobinemia |
| الوصف: | Nitrate (NO3¯ ) is an effective non-protein nitrogen source for gut microbes and reduces enteric methane (CH4 ) production in ruminants. Nitrate is reduced to ammonia by rumen bacteria with nitrite (NO2¯ ) produced as an intermediate. The absorption of NO2¯ can cause methaemoglobinaemia in ruminants. Metabolism of NO3¯ and NO2¯ in blood and animal tissues forms nitric oxide (NO) which has profound physiological effects in ruminants and has been shown to increase glucose uptake and insulin secretion in rodents and humans. We hypothesized that absorption of small quantities of NO2¯ resulting from a low-risk dose of dietary NO3¯ will increase insulin sensitivity (SI ) and glucose uptake in sheep. We evaluated the effect of feeding sheep with a diet supplemented with 18 g NO3¯ /kg DM or urea (Ur) isonitrogenously to NO3¯ , on insulin and glucose dynamics. A glucose tolerance test using an intravenous bolus of 1 ml/kg LW of 24% (w/v) glucose was conducted in twenty sheep, with 10 sheep receiving 1.8% supplementary NO3¯ and 10 receiving supplementary urea isonitrogenously to NO3¯ . The MINMOD model used plasma glucose and insulin concentrations to estimate basal plasma insulin (Ib ) and basal glucose concentration (Gb ), insulin sensitivity (SI ), glucose effectiveness (SG ), acute insulin response (AIRg) and disposition index (DI). Nitrate supplementation had no effect on Ib (p > .05). The decrease in blood glucose occurred at the same rate in both dietary treatments (SG ; p = .60), and there was no effect of NO3¯ on either Gb , SI , AIRg or DI. This experiment found that the insulin dynamics assessed using the MINMOD model were not affected by NO3¯ administered to fasted sheep at a low dose of 1.8% NO3¯ in the diet. |
| تدمد: | 1439-0396 0931-2439 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c20f9ae7dcd7c50fb40f9d09556460d https://doi.org/10.1111/jpn.13174 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....6c20f9ae7dcd7c50fb40f9d09556460d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14390396 09312439 |
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