Atherosclerotic Plaque Ulceration in the Symptomatic Internal Carotid Artery Is Associated With Nonlacunar Ischemic Stroke
| العنوان: | Atherosclerotic Plaque Ulceration in the Symptomatic Internal Carotid Artery Is Associated With Nonlacunar Ischemic Stroke |
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| المؤلفون: | Marjon J. van Gils, S. Rozie, Diederik W.J. Dippel, Aad van der Lugt, Tessa Jansen, Thomas T. de Weert, Philip J. Homburg |
| المساهمون: | Radiology & Nuclear Medicine, Health Economics (HE), Neurology |
| المصدر: | Stroke, 41(6), 1151-1156. Lippincott Williams & Wilkins |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Carotid Artery Diseases, Male, medicine.medical_specialty, Lacunar stroke, Carotid arteries, Brain Ischemia, Cerebral circulation, medicine.artery, Internal medicine, medicine, Humans, cardiovascular diseases, Stroke, Aged, Advanced and Specialized Nursing, business.industry, Amaurosis fugax, Middle Aged, Atherosclerosis, medicine.disease, Ischemic stroke, Etiology, Cardiology, Female, Neurology (clinical), Radiology, medicine.symptom, Internal carotid artery, Tomography, X-Ray Computed, Cardiology and Cardiovascular Medicine, business, Carotid Artery, Internal |
| الوصف: | Background and Purpose— Atherosclerotic carotid plaque ulceration is considered a marker of previous plaque rupture and subsequent thromboembolism. It can be accurately detected with multidetector CTA. We hypothesized that atherosclerotic plaque ulceration is associated with nonlacunar ischemic stroke rather than lacunar stroke. Methods— Prospectively, 750 consecutive patients with transient ischemic attack or ischemic stroke symptoms in the anterior cerebral circulation were evaluated for the presence of atherosclerotic plaque ulceration in the symptomatic carotid artery with multidetector CTA. Patients with stroke attributable to cardiac embolism or other specific etiologies and patients with amaurosis fugax were excluded. Ischemic strokes in the remaining 534 patients were classified as nonlacunar (n=236) or lacunar (n=298) based on clinical symptoms and multidetector CT of the brain. Ulceration was defined as extension of contrast material beyond the vascular lumen into the surrounding plaque. Results— Plaque ulceration in the symptomatic carotid artery was more common in nonlacunar strokes (n=47; 20%) as compared to lacunar strokes (n=20; 7%; P Conclusions— Atherosclerotic carotid plaque ulceration is associated with nonlacunar ischemic stroke, independent of the degree of carotid stenosis. These results suggest that nonlacunar stroke and lacunar stroke are caused by different pathophysiological mechanisms. |
| تدمد: | 1524-4628 0039-2499 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c504e890032d307aab6f7f95732ece2 https://doi.org/10.1161/strokeaha.109.576256 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6c504e890032d307aab6f7f95732ece2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244628 00392499 |
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