Inflammatory bowel disease in children with systemic juvenile idiopathic arthritis
| العنوان: | Inflammatory bowel disease in children with systemic juvenile idiopathic arthritis |
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| المؤلفون: | Maller, Justine, Fox, Emily, Park, K. T., Paul, Sarah Sertial, Baszis, Kevin, Borocco, Charlotte, Prahalad, Sampath, Quartier, Pierre, Reinhardt, Adam, Schonenberg-Meinema, Dieneke, Shipman-Duensing, Lauren, Terreri, Maria Teresa, Simard, Julia, Lavi, Idit, Chalom, Elizabeth, Hsu, Joyce, Zisman, Devy, Mellins, Elizabeth D., Abramson, L., Anderson, E., Andrew, M., Battle, N., Becker, M., Benham, H., Beukelman, T., Birmingham, J., Blier, P., Brown, A., Brunner, H., Cabrera, A., Canter, D., Carlton, D., Caruso, B., Ceracchio, L., Chang, J., Charpentier, P., Clark, K., Dean, J., Dedeoglu, F., Feldman, B., Ferguson, P., Fox, M., Francis, K., Gervasini, M., Goldsmith, D., Gorton, G., Gottlieb, B., Graham, T., Griffin, T., Grosbein, H. |
| المساهمون: | Graduate School, Paediatric Infectious Diseases / Rheumatology / Immunology, AII - Inflammatory diseases, Amsterdam Gastroenterology Endocrinology Metabolism |
| المصدر: | Journal of rheumatology, 48(4), 567-574. Journal of Rheumatology J Rheumatol |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Immunology, Arthritis, Cytokine inhibitors, Inflammatory bowel disease, digestive system, Article, Etanercept, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Systemic juvenile idiopathic arthritis, Internal medicine, Humans, Immunology and Allergy, Medicine, Pediatric rheumatology, Registries, Family history, Child, 030203 arthritis & rheumatology, business.industry, Macrophage Activation Syndrome, Incidence (epidemiology), Inflammatory Bowel Diseases, medicine.disease, Arthritis, Juvenile, digestive system diseases, Canakinumab, 030104 developmental biology, Macrophage activation syndrome, Cohort, Autoinflammation, business, medicine.drug |
| الوصف: | ObjectiveThe incidence of inflammatory bowel disease (IBD) in juvenile idiopathic arthritis (JIA) is higher than in the general pediatric population. However, reports of IBD in the systemic JIA (sJIA) subtype are limited. We sought to characterize sJIA patients diagnosed with IBD and to identify potential contributing risk factors.MethodsUsing an internationally distributed survey, we identified 16 patients with sJIA who were subsequently diagnosed with IBD (sJIA-IBD cohort). Five hundred twenty-two sJIA patients without IBD were identified from the CARRA Legacy Registry and served as the sJIA-only cohort for comparison. Differences in demographic, clinical characteristics, and therapy were assessed using chi-square test, Fisher exact test,t-test, and univariate and multivariate logistic regression, as appropriate.ResultsOf the patients with sJIA-IBD, 75% had a persistent sJIA course and 25% had a history of macrophage activation syndrome. sJIA-IBD subjects were older at sJIA diagnosis, more often non-White, had a higher rate of IBD family history, and were more frequently treated with etanercept or canakinumab compared to sJIA-only subjects. Sixty-nine percent of sJIA-IBD patients successfully discontinued sJIA medications following IBD diagnosis, and sJIA symptoms resolved in 9 of 12 patients treated with tumor necrosis factor-α (TNF-α) inhibitors.ConclusionIBD in the setting of sJIA is a rare occurrence. The favorable response of sJIA symptoms to therapeutic TNF-α inhibition suggests that the sJIA-IBD cohort may represent a mechanistically distinct sJIA subgroup. Our study highlights the importance of maintaining a high level of suspicion for IBD when gastrointestinal involvement occurs in patients with sJIA and the likely broad benefit of TNF-α inhibition in those cases. |
| اللغة: | English |
| تدمد: | 0315-162X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c555fdb7ebf19e6b6a9d09a75eadffa http://www.scopus.com/inward/record.url?scp=85104818803&partnerID=8YFLogxK |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6c555fdb7ebf19e6b6a9d09a75eadffa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0315162X |
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