Angiogenesis and Growth of Murine Colon Carcinoma are Dependent on Infiltrating Leukocytes
| العنوان: | Angiogenesis and Growth of Murine Colon Carcinoma are Dependent on Infiltrating Leukocytes |
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| المؤلفون: | Junya Yoneda, Corazon D. Bucana, Jerald J. Killion, Isaiah J. Fidler |
| المصدر: | Cancer Biotherapy and Radiopharmaceuticals. 14:221-230 |
| بيانات النشر: | Mary Ann Liebert Inc, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Male, Cancer Research, Pathology, medicine.medical_specialty, Angiogenesis, Spleen, Cecal Neoplasms, Mice, SCID, Neovascularization, Mice, Cecum, Leukocytes, medicine, Carcinoma, Animals, Radiology, Nuclear Medicine and imaging, Doxorubicin, Pharmacology, Mice, Inbred BALB C, Neovascularization, Pathologic, business.industry, Tumor-infiltrating lymphocytes, General Medicine, medicine.disease, Drug Resistance, Multiple, medicine.anatomical_structure, Oncology, Tumor progression, Colonic Neoplasms, medicine.symptom, business, Cell Division, medicine.drug |
| الوصف: | We determined whether the angiogenesis and growth of murine colon carcinomas growing in the wall of the cecum is dependent on infiltrating leukocytes. Syngeneic BALB/c or SCID mice were treated with a myelosuppressive, maximally tolerated dose of doxorubicin. Parental or multidrug resistant CT-26 colon carcinoma cells were implanted into the cecal wall 3 days after the second intravenous injection of doxorubicin. Control mice developed large, well-vascularized tumors, whereas doxorubicin-pretreated mice did not. Intravenous injection of spleen cells from normal BALB/c or SCID mice one day prior to tumor cell implantation reversed the decreased vascularity and tumorigenicity. The production of proangiogenic molecules and microvessel density in tumors directly correlated with the number of infiltrating leukocytes, suggesting that tumor-infiltrating leukocytes are essential to angiogenesis of murine colon carcinomas. |
| تدمد: | 1557-8852 1084-9785 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c97238758a88a61adc5cbe63c664d04 https://doi.org/10.1089/cbr.1999.14.221 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....6c97238758a88a61adc5cbe63c664d04 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15578852 10849785 |
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