أعرض في EDS

Familial Hypercholesterolemia and Lipoprotein(a): Two Partners in Crime?

التفاصيل البيبلوغرافية
العنوان: Familial Hypercholesterolemia and Lipoprotein(a): Two Partners in Crime?
المؤلفون: Rodrigo Alonso, Rosa Argüeso, Pilar Álvarez-Baños, Ovidio Muñiz-Grijalvo, Jose Luis Diaz-Diaz, Pedro Mata
المصدر: Current Atherosclerosis Reports. 24:427-434
بيانات النشر: Springer Science and Business Media LLC, 2022.
سنة النشر: 2022
مصطلحات موضوعية: Hyperlipoproteinemia Type II, Humans, Aortic Valve Stenosis, Cholesterol, LDL, Crime, Cardiology and Cardiovascular Medicine, Lipoprotein(a)
الوصف: Familial hypercholesterolemia is a high cardiovascular risk disorder. We will review the role of lipoprotein(a) in cardiovascular risk and in aortic valve stenosis in familial hypercholesterolemia, as well as its association with their phenotype, and strategies to identify this high-risk population.Patients with familial hypercholesterolemia have higher lipoprotein(a) levels mainly due to an increased frequency of LPA variants, and the cardiovascular risk is increased twofolds when both conditions coexist. Also, an increased risk for aortic valve stenosis and valve replacement has been observed with high lipoprotein(a) levels. Assessment of lipoprotein(a) during the cascade screening for familial hypercholesterolemia is a good opportunity to identify this high-risk population. High cardiovascular risk in familial hypercholesterolemia is increased even more when lipoprotein(a) is also elevated. Measurement of lipoprotein(a) in these patients is crucial to identify those subjects who need to intensify LDL-cholesterol reduction pending availability of lipoprotein(a)-specific treatments.
تدمد: 1534-6242
1523-3804
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ca448c8433405f61a986c9271214734
https://doi.org/10.1007/s11883-022-01019-5
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....6ca448c8433405f61a986c9271214734
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15346242
15233804