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Increased neutrophil-lymphocyte ratio predicts recurrence in patients with well-differentiated pancreatic neuroendocrine neoplasm based on the 2017 World Health Organization classification

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العنوان: Increased neutrophil-lymphocyte ratio predicts recurrence in patients with well-differentiated pancreatic neuroendocrine neoplasm based on the 2017 World Health Organization classification
المؤلفون: Kyohei Ariake, Takanori Morikawa, Kunihiro Masuda, Masamichi Mizuma, Hironobu Sasano, Shuichi Aoki, Fumiyoshi Fujishima, Kei Nakagawa, Takashi Kamei, Michiaki Unno, Tatsuo Hata, Takeshi Aoki, Shimpei Maeda, Kei Kawaguchi, Tatsuyuki Takadate, Takayuki Miura, Hideo Ohtsuka, Masaharu Ishida
المصدر: BMC Surgery
BMC Surgery, Vol 21, Iss 1, Pp 1-10 (2021)
سنة النشر: 2020
مصطلحات موضوعية: Oncology, medicine.medical_specialty, Multivariate analysis, Neutrophils, lcsh:Surgery, World Health Organization, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Lymphocyte Count, Lymphocytes, Univariate analysis, Receiver operating characteristic, Proportional hazards model, business.industry, Systemic immune-inflammatory marker, Hazard ratio, Univariate, General Medicine, lcsh:RD1-811, Prognosis, Confidence interval, Surgery, Pancreatic Neuroendocrine Neoplasm, Pancreatic Neoplasms, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Pancreatic neuroendocrine neoplasm (PanNEN), Neoplasm Recurrence, Local, business, Neutrophil–lymphocyte ratio (NLR), Research Article
الوصف: Background The prognostic values of inflammation-based markers in well-differentiated pancreatic neuroendocrine neoplasms, diagnosed according to the new 2017 World Health Organization classification, have remained unclear. Therefore, we assessed the ability to predict the recurrence of such markers after curative resection in patients with these neoplasms. Methods Circulating/systemic neutrophil–lymphocyte, monocyte–lymphocyte, platelet–lymphocyte, and platelet–white cell ratios were evaluated in 120 patients who underwent curative resection for well-differentiated pancreatic neuroendocrine neoplasms without synchronous distant metastasis between 2001 and 2018. Recurrence-free-survival and overall survival were compared using Kaplan–Meier analysis and log-rank tests. Univariate or multivariate analyses, using a Cox proportional hazards model, were used to calculate hazard ratios with 95% confidence intervals. Results Univariate analysis demonstrated that preoperative neutrophil–lymphocyte ratio, tumor size, European Neuroendocrine Tumor Society TMN classification, 2017 World Health Organization classification, and venous invasion were associated with recurrence. The optimal preoperative neutrophil–lymphocyte ratio cut-off value was 2.62, based on receiver operating characteristic curve analysis. In multivariate analysis, a higher preoperative neutrophil–lymphocyte ratio (HR = 3.49 95% CI 1.05–11.7; P = 0.042) and 2017 World Health Organization classification (HR = 8.81, 95% CI 1.46–168.2; P = 0.015) were independent recurrence predictors. Conclusions The circulating/systemic neutrophil–lymphocyte ratio is a useful and convenient preoperative prognostic marker of recurrence in patients with well-differentiated pancreatic neuroendocrine neoplasm based on the 2017 World Health Organization classification.
تدمد: 1471-2482
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce035543a0cf19e4377321d06cae7d2
https://pubmed.ncbi.nlm.nih.gov/33789657
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....6ce035543a0cf19e4377321d06cae7d2
قاعدة البيانات: OpenAIRE
الوصف
تدمد:14712482