Rate Constant of Tension-Induced Pore Formation in Lipid Membranes
| العنوان: | Rate Constant of Tension-Induced Pore Formation in Lipid Membranes |
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| المؤلفون: | Marina Belaya, Victor Levadny, Taka-aki Tsuboi, Masahito Yamazaki |
| المصدر: | Langmuir. 29:3848-3852 |
| بيانات النشر: | American Chemical Society (ACS), 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Tension (physics), Chemistry, Bilayer, Vesicle, Kinetics, Analytical chemistry, Thermodynamics, Phosphatidylglycerols, Surfaces and Interfaces, Condensed Matter Physics, Surface tension, Membrane Lipids, Membrane, Reaction rate constant, Time course, Phosphatidylcholines, Electrochemistry, Surface Tension, General Materials Science, Unilamellar Liposomes, Spectroscopy |
| الوصف: | We investigated the effects of tension induced by micropipet aspiration on giant unilamellar vesicles (GUVs) composed of dioleoylphosphatidylglycerol (DOPG) and dioleoylphosphatidylcholine (DOPC). We analyzed the time course of the fraction of intact GUVs among all of the GUVs under constant tension σ and obtained the rate constants of pore formation kp(σ). To determine kp, we developed an approach using the mean first passage time. The fitting of the theoretical curves of kp versus σ to the experimental data determined the line tension of a prepore, Γ. The value of Γ of a DOPG/DOPC bilayer was smaller than that of a DOPC bilayer. |
| تدمد: | 1520-5827 0743-7463 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf4d227da3605c9b7dd2db37ab91116 https://doi.org/10.1021/la304662p |
| رقم الأكسشن: | edsair.doi.dedup.....6cf4d227da3605c9b7dd2db37ab91116 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15205827 07437463 |
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