Intravoxel Incoherent Motion of Colon Cancer Liver Metastases for the Assessment of Response to Antiangiogenic Treatment: Results from a Pilot Study
| العنوان: | Intravoxel Incoherent Motion of Colon Cancer Liver Metastases for the Assessment of Response to Antiangiogenic Treatment: Results from a Pilot Study |
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| المؤلفون: | Aysegul Oz, Bedriye Koyuncu Sokmen, Sadık Server, Esat Namal, Numan Cem Balci, Nagihan Inan |
| المصدر: | Med Princ Pract |
| بيانات النشر: | S. Karger AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Organoplatinum Compounds, 020205 medical informatics, Combination therapy, Bevacizumab, Colorectal cancer, Leucovorin, Angiogenesis Inhibitors, Pilot Projects, 02 engineering and technology, Metastasis, 03 medical and health sciences, Antineoplastic Agents, Immunological, Antineoplastic Combined Chemotherapy Protocols, 0202 electrical engineering, electronic engineering, information engineering, medicine, Humans, Effective diffusion coefficient, Prospective Studies, Intravoxel incoherent motion, Original Paper, business.industry, Liver Neoplasms, General Medicine, Middle Aged, medicine.disease, Diffusion Magnetic Resonance Imaging, Colonic Neoplasms, Camptothecin, Female, Fluorouracil, 030101 anatomy & morphology, Nuclear medicine, business, Perfusion, Diffusion MRI, medicine.drug |
| الوصف: | Objective: This study was aimed at evaluating the intravoxel incoherent motion (IVIM) parameter alterations of liver metastases of colorectal carcinoma (CRC) during antiangiogenic bevacizumab combination therapy. Methods: Twenty-five patients with CRC liver metastases treated with bevacizumab in combination with FOLFOX-or-FOLFIRI protocols were enrolled in the study. MRI was performed using a 1.5-tesla scanner pre-treatment (PT) and at 3, 6, and 9 months of therapy. Routine abdominal MRI sequences and an IVIM-DWI (diffusion-weighted imaging) sequence were obtained. The IVIM-DWI sequence was executed with 16 b-values varying from 0 to 1,400 s/mm2. The mean values of apparent diffusion coefficient (ADC), true diffusion (D), pseudodiffusion (D*), and perfusion fraction (f) of each metastasis were obtained for all b-values, and the time-related changes were recorded to analyze the chronologic responses to antiangiogenic therapy. The RECIST 1.1 criteria were used for the evaluation of treatment response. Results: The diameters of the metastases diminished significantly at 9 months when compared with PT (p = 0.03). The D (p = 0.10) and ADC (p = 0.21) values of the metastases increased at 9 months of therapy. D* was the highest at 3 months (p =0.24); it decreased at 6 (p =0.97) and 9 months (p =0.87) of therapy. The f value had peaked at 3 months (p =0.51) and started to decrease thereafter. At 6 months, f decreased to the lowest values (p =0.12). Conclusion: IVIM parameters, particularly the perfusion fraction, may quantitatively reflect the response to antiangiogenic treatment. The antiangiogenic response manifests after 3 months of therapy before the RECIST-related response. |
| تدمد: | 1423-0151 1011-7571 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d035ccdb23a36f294f9332d2a3f63a9 https://doi.org/10.1159/000505814 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6d035ccdb23a36f294f9332d2a3f63a9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230151 10117571 |
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