Antimicrobial peptides: mechanism of action, activity and clinical potential
| العنوان: | Antimicrobial peptides: mechanism of action, activity and clinical potential |
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| المؤلفون: | Jian Kang, Qiyu Zhang, Xurui Cheng, Zhi-Bin Yan, Jun Liu, Yueming Meng, Jun-Jie Ma, Gang Shao, Caiyun Fu, Xiang-Yu Hong |
| المصدر: | Military Medical Research, Vol 8, Iss 1, Pp 1-25 (2021) Military Medical Research |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pore Forming Cytotoxic Proteins, Medicine (General), Antimicrobial peptides, Computational biology, Review, Mechanism of action, Antimicrobial resistance, Theta defensin, Antibiotic resistance, R5-920, medicine, Humans, Low toxicity, business.industry, Biological activity, General Medicine, Bacterial Infections, Antimicrobial, Clinical application, Anti-Bacterial Agents, Military Science, medicine.symptom, business |
| الوصف: | The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome antibiotic resistance, antimicrobial peptides (AMPs) that are produced from the synthetic and natural sources demonstrate a broad-spectrum antimicrobial activity with the high specificity and low toxicity. These peptides possess distinctive structures and functions by employing sophisticated mechanisms of action. This comprehensive review provides a broad overview of AMPs from the origin, structural characteristics, mechanisms of action, biological activities to clinical applications. We finally discuss the strategies to optimize and develop AMP-based treatment as the potential antimicrobial and anticancer therapeutics. Supplementary Information The online version contains supplementary material available at 10.1186/s40779-021-00343-2. |
| اللغة: | English |
| تدمد: | 2054-9369 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2d4434cd1c44ef2d86399244b5d430 https://doaj.org/article/b049ecc3dec749f385cd157c7594726d |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6d2d4434cd1c44ef2d86399244b5d430 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 20549369 |
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