The prognosis in spindle-cell sarcoma depends on the expression of cyclin-dependent kinase inhibitor p27Kip1 and cyclin E
| العنوان: | The prognosis in spindle-cell sarcoma depends on the expression of cyclin-dependent kinase inhibitor p27Kip1 and cyclin E |
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| المؤلفون: | Shinya Kawai, Ritsuko Ohi, Shigeto Kawauchi, Kohsuke Sasaki, Koichiro Ihara, Yoshinari Goto, Kenzo Ikemoto |
| المصدر: | Cancer Science. 94:412-417 |
| بيانات النشر: | Wiley, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Male, Cancer Research, Cyclin E, Cell Cycle Proteins, Soft Tissue Neoplasms, Immunoenzyme Techniques, Cyclin-dependent kinase, Gene expression, Biopsy, medicine, Humans, Survival rate, Neoplasm Staging, biology, medicine.diagnostic_test, Tumor Suppressor Proteins, Sarcoma, General Medicine, Middle Aged, Prognosis, medicine.disease, Primary tumor, Survival Rate, Oncology, biology.protein, Cancer research, Female, Spindle cell sarcoma, Cyclin-Dependent Kinase Inhibitor p27 |
| الوصف: | The aim of the present study was to examine the prognostic significance of p27(Kip1) and cyclin E expression in patients with spindle-cell soft tissue sarcomas. In 46 cases of spindle-cell sarcoma including 17 pre-operative biopsy materials, the expression of p27(Kip1) and cyclin E was immunohistochemically examined. The expression of p27(Kip1) decreased in the nuclei of metastatic primary tumor cells (stage IV), whereas the expression of cyclin E increased in those lesions. On univariate analysis, when the expression of p27(Kip1) and cyclin E was analyzed together, patients with spindle-cell sarcoma exhibiting low expression of p27(Kip1) and high expression of cyclin E showed lower distant-metastasis-free survival (DMFS) and overall survival (OS) than those with other combinations of the two parameters (both P < 0.0001). Multivariate analysis revealed that patients with low p27(Kip1) and high cyclin E expression also showed a decrease in DMFS (P = 0.0007, relative risk = 21.3) and OS (P = 0.005, relative risk = 20.8). These results suggest that the combination analysis of p27(Kip1) and cyclin E expression even in biopsy specimens allows the prediction of the clinical behavior of spindle-cell sarcoma. |
| تدمد: | 1349-7006 1347-9032 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d5cc3315c5544192c679541b5399f53 https://doi.org/10.1111/j.1349-7006.2003.tb01456.x |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6d5cc3315c5544192c679541b5399f53 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13497006 13479032 |
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