أعرض في EDS

Combinatorial synthesis of chemical building blocks 1. Azomethines

التفاصيل البيبلوغرافية
العنوان: Combinatorial synthesis of chemical building blocks 1. Azomethines
المؤلفون: Andrey A. Tolmachev, Sergey V. Ryabukhin, Alexander Shivanyuk, Dmitriy M. Panov, Sergey E. Pipko, Andrey S. Plaskon, Alexander Chuprina
المصدر: Molecular Diversity. 16:625-637
بيانات النشر: Springer Science and Business Media LLC, 2012.
سنة النشر: 2012
مصطلحات موضوعية: Thiosemicarbazones, Molecular Structure, Pyridines, Chemistry, Organic Chemistry, Condensation, General Medicine, Combinatorial synthesis, Combinatorial chemistry, Catalysis, Scavenger (chemistry), Inorganic Chemistry, Hydrolysis, chemistry.chemical_compound, Acid catalyzed, Yield (chemistry), Drug Discovery, Pyridine, Combinatorial Chemistry Techniques, Amines, Physical and Theoretical Chemistry, Azo Compounds, Molecular Biology, Information Systems
الوصف: 128 Azomethines were synthesized through condensation of carbonyl compounds with various amines in pyridine in the presence of Me(3)SiCl as promoter and water scavenger in 58-98 % yield. Et(3)N was added to reaction mixtures before precipitating the product with H(2)O to prevent acid catalyzed hydrolysis of the C=N bond. The scope and limitation of the method are discussed. High yields and simple setup/workup procedure make this method suitable for the combinatorial synthesis of azomethines, which are suitable as starting materials for high throughput synthesis of various combinatorial libraries. The azomethines synthesized were used as starting materials in a one-pot combinatorial synthesis of amines and amides.
تدمد: 1573-501X
1381-1991
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d6a929d953eb9f984241fc252f98d46
https://doi.org/10.1007/s11030-012-9407-9
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....6d6a929d953eb9f984241fc252f98d46
قاعدة البيانات: OpenAIRE
الوصف
تدمد:1573501X
13811991