Ketamine Reduces the Cell Death Following Inflammatory Pain in Newborn Rat Brain
| العنوان: | Ketamine Reduces the Cell Death Following Inflammatory Pain in Newborn Rat Brain |
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| المؤلفون: | Kanwaljeet J. S. Anand, Umesh Narsinghani, Cynthia R. Rovnaghi, Richard W. Hall, Sarita Garg, Adnan T. Bhutta |
| المصدر: | Pediatric Research. 62:283-290 |
| بيانات النشر: | Springer Science and Business Media LLC, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Male, Pain Threshold, medicine.medical_specialty, Neurology, Central nervous system, Pain, Cerebro, Random Allocation, Pregnancy, Animals, Humans, Medicine, Ketamine, Pain Measurement, Inflammation, Analgesics, Radial arm maze, Behavior, Animal, Cell Death, business.industry, Infant, Newborn, Glutamate receptor, Antagonist, Brain, Rats, medicine.anatomical_structure, Animals, Newborn, Anesthesia, Pediatrics, Perinatology and Child Health, NMDA receptor, Female, business, Proto-Oncogene Proteins c-fos, Infant, Premature, medicine.drug |
| الوصف: | Premature infants experience untreated repetitive pain that may alter their brain development. Effects of ketamine and repetitive pain on cellular death and subsequent behavior were studied in neonatal rats. Rat pups were randomized to undisturbed controls (C), 4% formalin injection (F), ketamine alone (K, 5 mg/kg) or formalin plus ketamine (KF) and were assessed for neuroactivation with Fos protein, cellular death with FluoroJade-B, cognition with the radial arm maze, and pain thresholds with the hot-plate. Greater Fos expression and cell death occurred in F vs. C groups in defined brain areas at 1 and 4 h in F compared with other groups. Cell death was accentuated 3.3-fold in cortical areas and 1.6-fold in subcortical areas in the F compared with the C group following repetitive pain and sacrifice 18-20 h later. These effects were ameliorated by ketamine. Compared with the F group, all other groups demonstrated greater exploratory and rearing behaviors and decreased time for bait consumption at 1-h and 3-h intervals. Significantly greater thermal pain latencies occurred in the KF and F groups. Repetitive neonatal pain accentuates neuronal excitation and cell death in developmentally regulated cortical and subcortical areas, which decreases the acquisition of visual-spatial clues, short-term and long-term memory, and increases pain latencies. Ketamine analgesia mitigates most of these effects. |
| تدمد: | 1530-0447 0031-3998 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d7b9797654b9e28cdade823c97fee68 https://doi.org/10.1203/pdr.0b013e3180986d2f |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6d7b9797654b9e28cdade823c97fee68 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15300447 00313998 |
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