Reference intervals for bone turnover markers in Spanish premenopausal women
| العنوان: | Reference intervals for bone turnover markers in Spanish premenopausal women |
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| المؤلفون: | Núria Guañabens, Xavier Filella, Ana Monegal, Carmen Gómez-Vaquero, María Bonet, Dolors Buquet, Enrique Casado, Dacia Cerdá, Alba Erra, Silvia Martinez, Núria Montalá, Concepción Pitarch, Eduardo Kanterewicz, Miquel Sala, Xavier Surís, Ferran Torres, null on behalf of the LabOscat Study Gro |
| المساهمون: | Universitat de Barcelona |
| المصدر: | Dipòsit Digital de la UB Universidad de Barcelona Recercat. Dipósit de la Recerca de Catalunya instname |
| بيانات النشر: | Walter de Gruyter GmbH, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Clinical Biochemistry, Osteoporosis, Physiology, Body Mass Index, Bone remodeling, 0302 clinical medicine, Reference Values, Ossos, Vitamin D, biology, Biochemical markers, General Medicine, Middle Aged, Menopause, Parathyroid Hormone, Marcadors bioquímics, Osteocalcin, Female, Bone Remodeling, Procollagen, Type I collagen, Menopausa, Adult, medicine.medical_specialty, Urinary system, Enzyme-Linked Immunosorbent Assay, 030209 endocrinology & metabolism, Collagen Type I, 03 medical and health sciences, N-terminal telopeptide, Internal medicine, medicine, Humans, Espanya, Bones, business.industry, Biochemistry (medical), Osteoporosi, Alkaline Phosphatase, medicine.disease, Peptide Fragments, Reference intervals, 030104 developmental biology, Endocrinology, Premenopause, Spain, biology.protein, Peptides, business, Body mass index, Biomarkers |
| الوصف: | The aims of this study were to establish robust reference intervals and to investigate the factors influencing bone turnover markers (BTMs) in healthy premenopausal Spanish women.A total of 184 women (35–45 years) from 13 centers in Catalonia were analyzed. Blood and second void urine samples were collected between 8 a.m. and 10 a.m. after an overnight fast. Serum procollagen type I amino-terminal propeptide (PINP) and serum cross-linked C-terminal telopeptide of type I collagen (CTX-I) were measured by two automated assays (Roche and IDS), bone alkaline phosphatase (bone ALP) by ELISA, osteocalcin (OC) by IRMA and urinary NTX-I by ELISA. PTH and 25-hydroxyvitamin D (25OHD) levels were measured. All participants completed a questionnaire on lifestyle factors.Reference intervals were: PINP: 22.7–63.1 and 21.8–65.5 μg/L, bone ALP: 6.0–13.6 μg/L, OC: 8.0–23.0 μg/L, CTX-I: 137–484 and 109–544 ng/L and NTX-I: 19.6–68.9 nM/mM. Oral contraceptive pills (OCPs) influenced PINP (p=0.007), and low body mass index (BMI) was associated with higher BTMs except for bone ALP. Women under 40 had higher median values of most BTMs. CTX-I was influenced by calcium intake (p=0.010) and PTH (p=0.007). 25OHD levels did not influence BTMs. Concordance between the two automated assays for PINP and particularly CTX-I was poor.Robust reference intervals for BTMs in a Southern European country are provided. The effects of OCPs and BMI on their levels are significant, whilst serum 25OHD levels did not influence BTMs. Age, calcium intake, BMI and PTH influenced CTX-I. The two automated assays for measuring PINP and CTX-I are not interchangeable. |
| وصف الملف: | application/pdf |
| تدمد: | 1437-4331 1434-6621 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dbe55ec1de66ff27205329d0f4e4bb6 https://doi.org/10.1515/cclm-2015-0162 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6dbe55ec1de66ff27205329d0f4e4bb6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14374331 14346621 |
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