Predictors for bronchoalveolar lavage recovery failure in diffuse parenchymal lung disease
| العنوان: | Predictors for bronchoalveolar lavage recovery failure in diffuse parenchymal lung disease |
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| المؤلفون: | Kazuki Furuhashi, Masato Karayama, Noriyuki Enomoto, Keigo Koda, Takafumi Suda, Naoki Inui, Yutaro Nakamura, Hideki Yasui, Hironao Hozumi, Yuzo Suzuki, Tomoyuki Fujisawa |
| المصدر: | Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) Scientific Reports |
| بيانات النشر: | Nature Portfolio, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Parenchymal lung disease, medicine.medical_specialty, Vital capacity, Science, Logistic regression, Bronchoalveolar Lavage, Article, 03 medical and health sciences, Medical research, 0302 clinical medicine, Clinical Decision Rules, Internal medicine, medicine, Humans, Pulmonologists, Aged, Retrospective Studies, 030203 arthritis & rheumatology, Multidisciplinary, Lung, medicine.diagnostic_test, business.industry, Reproducibility of Results, Middle Aged, respiratory system, Respiratory Function Tests, respiratory tract diseases, Bronchoalveolar lavage, medicine.anatomical_structure, Risk factors, 030228 respiratory system, Target site, Cohort, Medicine, Female, Lung Diseases, Interstitial, business, Bronchoalveolar Lavage Fluid |
| الوصف: | Bronchoalveolar lavage (BAL) plays a role in the diagnosis of diffuse parenchymal lung diseases (DPLD); however, poor BAL fluid (BALF) recovery results in low diagnostic reliability. BAL is relatively safe, but its indications should be carefully considered in patients with risks. Therefore, estimating the likelihood of recovery failure is helpful in clinical practice. This study aimed to clarify predictors of BALF recovery failure and to develop its simple-to-use prediction models. We detected the predictors applying a logistic regression model on clinical, physiological, and radiological data from 401 patients with DPLD (derivation cohort). The discrimination performance of the prediction models using these factors was evaluated by the c-index. In the derivation cohort, being a man, the forced expiratory volume in one second/forced vital capacity, and a BAL target site other than right middle lobe or left lingula were independent predictors. The c-indices of models 1 and 2 that we developed were 0.707 and 0.689, respectively. In a separate cohort of 234 patients (validation cohort), the c-indices of the models were 0.689 and 0.670, respectively. In conclusion, we developed and successfully validated simple-to-use prediction models useful for pulmonologists considering BAL indications or target sites, based on independent predictors for BALF recovery failure. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd8df9fa193e9910f3404083d8f7339 https://doaj.org/article/093e9f859d5c44fb906cdac1bf318bfa |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6dd8df9fa193e9910f3404083d8f7339 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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