Lactate Accumulation during Moderate Hypoxic Hypoxia in Neocortical Rat Brain
| العنوان: | Lactate Accumulation during Moderate Hypoxic Hypoxia in Neocortical Rat Brain |
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| المؤلفون: | Jean François Payen, Jean-Louis Pépin, Emmanuelle LeBars, Bernard Wuyam, Michel Décorps, Bernard Tropini, Patrick Levy |
| المصدر: | Scopus-Elsevier |
| بيانات النشر: | SAGE Publications, 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | medicine.medical_specialty, Hypoxic hypoxia, Central nervous system, Oxygene, Biology, 030218 nuclear medicine & medical imaging, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Animals, Lactic Acid, Hypoxia, computer.programming_language, Aspartic Acid, Brain, Water, Metabolism, Anatomy, Hypoxia (medical), Rat brain, Pathophysiology, Rats, Endocrinology, medicine.anatomical_structure, Neurology, Cerebral blood flow, Female, Neurology (clinical), medicine.symptom, Energy Metabolism, Cardiology and Cardiovascular Medicine, computer, 030217 neurology & neurosurgery |
| الوصف: | Neocortical metabolism was studied during moderate hypoxic hypoxia, reoxygenation, and postmortem periods in anesthetized normocapnic rats using 1H nuclear magnetic resonance (NMR) spectroscopic imaging. Rats were prepared with unilateral common carotid occlusion to determine the ipsilateral metabolic effects of inadequate cerebral blood flow (CBF) response to hypoxia. No difference in brain metabolism between the two hemispheres was found during the control period. Hypoxic hypoxia (Pao2 = 54.1 ± 5.8 mm Hg) resulted in a significant rise in neocortical lactate peak in both hemispheres, with an additional marked rise in the clamped side compared to the unclamped side (53 ± 27 vs. 22 ± 13% of postmortem value, p < 0.001). These lactate changes were not reversible within 30 min of reoxygenation in the clamped hemisphere. No changes in neocortical lactate peak were observed while elevating arterial lactate via intravenous lactate infusion without hypoxia. In addition, hypoxic hypoxia resulted in an apparent decrease in neocortical water and N-acetyl aspartate (NAA) signals, which were related to a shortening in T2 relaxation times. It is concluded that neocortical lactate is an early metabolic indicator during moderate hypoxic hypoxia in normocapnic conditions. |
| تدمد: | 1559-7016 0271-678X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e19ce4b46d3d26e69b668958b38cc06 https://doi.org/10.1097/00004647-199611000-00032 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6e19ce4b46d3d26e69b668958b38cc06 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15597016 0271678X |
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