Associations between lncRNA‐related polymorphisms and hepatocellular carcinoma risk: A two‐stage case–control study
| العنوان: | Associations between lncRNA‐related polymorphisms and hepatocellular carcinoma risk: A two‐stage case–control study |
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| المؤلفون: | Da-Lei Zhou, Caiyun He, Yue Li, Xiao Zhang, Qing Liu, Xin-Hua Yang, Tao Tang, Hui-Chan He, Zu-Lu Ye, Xuan Su, Jun-Ling Peng |
| المصدر: | Journal of Gastroenterology and Hepatology. 36:233-239 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Risk, Oncology, medicine.medical_specialty, Carcinoma, Hepatocellular, Population, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Genetic model, Biomarkers, Tumor, medicine, Humans, SNP, Genetic Predisposition to Disease, Allele, education, Genetic Association Studies, education.field_of_study, Models, Genetic, Hepatology, business.industry, Liver Neoplasms, Gastroenterology, Case-control study, Odds ratio, medicine.disease, digestive system diseases, Case-Control Studies, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Female, RNA, Long Noncoding, 030211 gastroenterology & hepatology, business |
| الوصف: | BACKGROUND AND AIM Single-nucleotide polymorphisms (SNPs) in long non-coding RNAs (lncRNAs) are potential biomarkers for cancer risk, but their association with hepatocellular carcinoma (HCC) is unclear. We examined the association of lncRNA-related SNPs with HCC susceptibility and explored the optimal genetic models for SNPs. METHODS Five candidate SNPs linked with digestive tumors were first genotyped in a screening population of 700 HCC and 2800 control cases. The association between each SNP and HCC risk was estimated by multivariate logistic regression adjusted by sex and age and recorded as odds ratio (OR) with 95% confidence interval. Significant associations were further tested in a validation population with 1140 HCC and 5115 control cases. Finally, the most appropriate genetic models for HCC-associated SNPs were identified using pairwise allele differences; the overall gene effects of each SNP were further evaluated based on optimal genetic models. RESULTS Three candidate SNPs, rs7315438, rs6983267, and rs10795668, showed statistical connections with HCC risk in the discovery stage. Among these, rs7315438 remained steadily significant in the validation stage; rs7315438 and rs10795668 both reached statistical threshold in the combined analysis of both stages. SNP rs7315438 (TC vs TT/CC, OR = 1.410, P |
| تدمد: | 1440-1746 0815-9319 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e2130534810586dae8dd10614c7fa84 https://doi.org/10.1111/jgh.15118 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....6e2130534810586dae8dd10614c7fa84 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14401746 08159319 |
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