Exploitation of Long-Lived 3IL Excited States for Metal–Organic Photodynamic Therapy: Verification in a Metastatic Melanoma Model
| العنوان: | Exploitation of Long-Lived 3IL Excited States for Metal–Organic Photodynamic Therapy: Verification in a Metastatic Melanoma Model |
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| المؤلفون: | Christopher Dorsey, Susan Monro, Huimin Yin, Randolph P. Thummel, Lars Kohler, Robie A. Hennigar, Abdellatif Chouai, Richard Lincoln, Ruifa Zong, Mat Stephenson, Sherri A. McFarland |
| المصدر: | Journal of the American Chemical Society. 135:17161-17175 |
| بيانات النشر: | American Chemical Society (ACS), 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Male, Lung Neoplasms, Metals in medicine, Metastatic melanoma, medicine.medical_treatment, Photodynamic therapy, Lung pathology, Photochemistry, Biochemistry, Ruthenium, Catalysis, Metal, Colloid and Surface Chemistry, Cell Line, Tumor, Organometallic Compounds, medicine, Humans, Lung, Melanoma, Diimine, Photosensitizing Agents, Chemistry, General Chemistry, Chromophore, Photochemotherapy, Excited state, visual_art, visual_art.visual_art_medium |
| الوصف: | Members of a family of Ru(II)-appended pyrenylethynylene dyads were synthesized, characterized according to their photophysical and photobiological properties, and evaluated for their collective potential as photosensitizers for metal-organic photodynamic therapy. The dyads in this series possess lowest-lying (3)IL-based excited states with lifetimes that can be tuned from 22 to 270 μs in fluid solution and from 44 to 3440 μs in glass at 77 K. To our knowledge, these excited-state lifetimes are the longest reported for Ru(II)-based dyads containing only one organic chromophore and lacking terminal diimine groups. These excited states proved to be extremely sensitive to trace amounts of oxygen, owing to their long lifetimes and very low radiative rates. Herein, we demonstrate that (3)IL states of this nature are potent photodynamic agents, exhibiting the largest photocytotoxicity indices reported to date with nanomolar light cytotoxicities at very short drug-to-light intervals. Importantly, these new agents are robust enough to maintain submicromolar PDT in pigmented metastatic melanoma cells, where the presence of melanin in combination with low oxygen tension is known to compromise PDT. This activity underscores the potential of metal-organic PDT as an alternate treatment strategy for challenging environments such as malignant melanoma. |
| تدمد: | 1520-5126 0002-7863 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e2a3c76eba8f3013238617c13697497 https://doi.org/10.1021/ja408426z |
| رقم الأكسشن: | edsair.doi.dedup.....6e2a3c76eba8f3013238617c13697497 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15205126 00027863 |
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