Cytocompatibility / Antibacterial Activity Trade-off for Knittable Wet-Spun Chitosan Monofilaments Functionalized by the In Situ Incorporation of Cu2+ and Zn2+
| العنوان: | Cytocompatibility / Antibacterial Activity Trade-off for Knittable Wet-Spun Chitosan Monofilaments Functionalized by the In Situ Incorporation of Cu2+ and Zn2+ |
|---|---|
| المؤلفون: | Renaud Passieux, Guillaume Sudre, Alexandra Montembault, Martine Renard, Agnès Hagege, Pierre Alcouffe, Ali Haddane, Marie Vandesteene, Nadège Boucard, Laurence Bordenave, Laurent David |
| المساهمون: | Ingénierie des Matériaux Polymères (IMP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Bioingénierie tissulaire (BIOTIS), Université de Bordeaux (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), MDB Texinov (MDB Texinov), MDB Texinov, CIC-IT INSERM Bordeaux, Separative Methods - Techniques séparatives, Institut des Sciences Analytiques (ISA), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Bussy, Agnès |
| المصدر: | ACS Biomaterials Science and Engineering ACS Biomaterials Science and Engineering, 2022, pp.acsbiomaterials.2c00079. ⟨10.1021/acsbiomaterials.2c00079⟩ |
| بيانات النشر: | American Chemical Society (ACS), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | cytocompatibility, Biomaterials, antibacterial, [CHIM.ANAL] Chemical Sciences/Analytical chemistry, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, complexation, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Biomedical Engineering, wet-spinning, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, chitosan, knittability |
| الوصف: | International audience; The wet spinning of cytocompatible, bioresorbable, and knittable chitosan (CTS) monofilaments would be advantageous for a variety of surgical applications. The complexation capacity of chitosan with Cu2+ or Zn2+ can be leveraged to enhance its antibacterial activity, but not at the expense of cytocompatibility. In this work, a wet-spinning process was adapted for the in situ incorporation of Cu2+ or Zn2+ with chitosan dopes to produce monofilaments at different drawing ratios (τtot) with various cation/glucosamine molar ratios, evaluated in the fibers (rCu,f and rZn,f). Cytocompatibility and antibacterial activity of wet-spun monofilaments were, respectively, quantified by in vitro live-dead assays on balb 3T3 and by different evaluations of the proliferation inhibition of Staphylococcus epidermidis (Gram+) and Escherichia coli (Gram−). Knittability was tested by a specific tensile test using a knitting needle and evaluated with an industrial knitting machine. It was found that rCu,f = 0.01 and rZn,f = 0.03 significantly increase the antibacterial activity without compromising cytocompatibility. Wet spinning with τtot = 1.6 allowed the production of knittable CTS-Cu monofilaments, as confirmed by knitting assays under industrial conditions. |
| تدمد: | 2373-9878 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e2ee6d4629f94038067a783360b7d82 https://doi.org/10.1021/acsbiomaterials.2c00079 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....6e2ee6d4629f94038067a783360b7d82 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 23739878 |
|---|