Overexpression of Acyl-CoA Ligase 4 (ACSL4) in Patients with Hepatocellular Carcinoma and its Prognosis
| العنوان: | Overexpression of Acyl-CoA Ligase 4 (ACSL4) in Patients with Hepatocellular Carcinoma and its Prognosis |
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| المؤلفون: | Xiao-Jie Sun, Ge-Liang Xu |
| المصدر: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| بيانات النشر: | International Scientific Literature, Inc., 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Adult, Male, Pathology, medicine.medical_specialty, Carcinoma, Hepatocellular, Databases, Factual, Biology, ACSL4, Disease-Free Survival, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, Text mining, Coenzyme A Ligases, medicine, Carcinoma, Biomarkers, Tumor, Humans, Stage (cooking), neoplasms, Molecular Biology, Survival analysis, Aged, business.industry, Liver Neoplasms, General Medicine, Middle Aged, medicine.disease, Prognosis, Immunohistochemistry, Survival Analysis, digestive system diseases, 030104 developmental biology, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Multivariate Analysis, Cancer research, Female, Acyl-CoA Oxidase, business |
| الوصف: | BACKGROUND Recently, accumulating studies have found that ACSL4 dysregulation is related to a great number of malignant tumors. The purpose of the present study was to explore the relationship between ACSL4 expression level and clinical prognosis of hepatocellular carcinoma (HCC) patients. MATERIAL AND METHODS The Oncomine and TCGA databases were used to predict the expression of ACSL4 mRNA in HCC and its association with HCC prognosis. Further, immunohistochemistry was performed to verify the ACSL4 protein expression in 116 paired HCC and adjacent normal tissues. Kaplan-Meier and cox analysis were performed to validate the correlation between ACSL4 expression and HCC prognosis. RESULTS We first used the Oncomine database to find that ACSL4 mRNA expression level was significantly higher in HCC tissues than that in normal tissues (p all |
| اللغة: | English |
| تدمد: | 1643-3750 1234-1010 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e6ee4b0e268bc0766fe597a56f56636 http://europepmc.org/articles/PMC5602145 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6e6ee4b0e268bc0766fe597a56f56636 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16433750 12341010 |
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