Effect of follicular helper T cells on the pathogenesis of asthma
| العنوان: | Effect of follicular helper T cells on the pathogenesis of asthma |
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| المؤلفون: | Pei Zhai, Jianbing Ding, Fengsen Li, Zhan Sun, Xiaojuan Ma, Wenyan Yu, Ting Wang |
| المصدر: | Experimental and Therapeutic Medicine |
| بيانات النشر: | Spandidos Publications, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, Cluster of differentiation, Interleukin, Articles, General Medicine, T helper cell, asthma, Biology, follicular helper T cell-related markers, CXCR5, respiratory tract diseases, ICOS LIGAND, Pathogenesis, follicular helper T cells, 03 medical and health sciences, Chemokine receptor, 030104 developmental biology, medicine.anatomical_structure, Immunology and Microbiology (miscellaneous), Immunology, medicine, Memory B cell |
| الوصف: | Follicular helper T (TFH) cells are considered to be a separate T helper cell subset, specifically to help memory B cell participate in humoral immunity. It has been reported that there is an association between the imbalance of TFH function and certain autoimmune diseases. However, to the best of our knowledge, the effect of TFH cells on the process of bronchial asthma has not been investigated. The aim of the present study was to investigate the associated markers of TFH cells in bronchial asthma-induced mice. In the current study, sensitized and long-term challenges induced a mouse asthmatic model and were used to investigate the associated markers of TFH cells in the pathogenesis of asthma. The results demonstrated that B cell lymphoma 6, inducible T-cell costimulator (ICOS), ICOS ligand, C-X-C chemokine receptor type 5 (CXCR5) and interleukin (IL)-21 protein and mRNA expression levels were higher in the asthma group, as compared with the control group. Furthermore, the ratio of cluster of differentiation (CD) 4+CXCR5+/CD4+ and CD4+CXCR5+ICOS+/CD4+CXCR5+ was significantly increased in the asthma group. The results of the current study suggest that TFH cells and associated markers may have a role in the pathogenesis of chronic bronchial asthma. |
| تدمد: | 1792-1015 1792-0981 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e72ff0ea701d2b35fe265e9a5dfc3d6 https://doi.org/10.3892/etm.2017.4627 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6e72ff0ea701d2b35fe265e9a5dfc3d6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17921015 17920981 |
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