Two‐pore channel protein TPC1 is a determining factor for the adaptation of proximal tubular phosphate handling
| العنوان: | Two‐pore channel protein |
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| المؤلفون: | Armin Just, Robert T. Mallmann, Sonja Grossmann, Faten Sleman, Norbert Klugbauer |
| المصدر: | Acta Physiologica. 237 |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Physiology |
| الوصف: | Two-pore channels (TPCs) constitute a small family of cation channels expressed in endo-lysosomal compartments. TPCs have been characterized as critical elements controlling CaImmunohistochemistry in combination with tubular markers were used to investigate TPC1 expression in proximal and distal tubules. The excretion of phosphate and ammonium, as well as urine volume and pH were studied in vivo, in response to dynamic challenges induced by bolus injection of parathyroid hormone or acid-base transitions via consecutive infusion of NaCl, NaIn TPC1-deficient mice, the PTH-induced rise in phosphate excretion was prolonged and exaggerated, and its recovery delayed in comparison to wild type littermates. In the acid-base transition experiment, TPC1-deficient mice showed an identical rise in phosphate excretion in response to NaWe conclude that TPC1 is expressed subapically in the proximal but not distal tubule and plays an important role in the dynamic adaptation of proximal tubular phosphate reabsorption towards enhanced, but not reduced absorption. |
| تدمد: | 1748-1716 1748-1708 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e852acca52334c5d7a19174b8dde503 https://doi.org/10.1111/apha.13914 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6e852acca52334c5d7a19174b8dde503 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17481716 17481708 |
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