التفاصيل البيبلوغرافية
العنوان:
Synthesis and biological properties of novel glucocorticoid androstene C-17 furoate esters
المؤلفون:
Deborah Hynx , Claire Ffoulkes-Jones , Gaynor Elizabeth Pilgrim , Sarah Jeffers , Sandra Haberthuer , Elisabeth Schaebulin , John R. Fozard , Thomas H. Keller , Bernard Cuenoud , David Bentley , Katharine L. Turner , Andrew Nicholls , David Beattie , Morris Tweed , Lucy Barker , Sarah Craig , David Beer , Christoph Walker , Paul Kirkham , Rowan Stringer , David Farr , David Andrew Sandham , K D Butler , Colin Howes , Simon J. Watson , Lazzaro Mazzoni , Gillian Spooner , Louise Bidlake , Pamela Tranter , Janet Maas
المصدر:
Bioorganicmedicinal chemistry . 12(19)
سنة النشر:
2004
مصطلحات موضوعية:
Stereochemistry , medicine.medical_treatment , Clinical Biochemistry , Pharmaceutical Science , Biological Availability , Thymus Gland , Pharmacology , Biochemistry , Chemical synthesis , Steroid , Cell Line , Structure-Activity Relationship , Glucocorticoid receptor , Receptors, Glucocorticoid , In vivo , Oral administration , Drug Discovery , Eosinophilia , medicine , Structure–activity relationship , Animals , Humans , Molecular Biology , Glucocorticoids , Chemistry , Tumor Necrosis Factor-alpha , Macrophages , Organic Chemistry , Esters , Organ Size , In vitro , Rats , Molecular Medicine , Androstenes , Glucocorticoid , medicine.drug , Protein Binding
الوصف:
A series of novel corticosteroid derivatives featuring C-17 furoate ester functionality have been synthesised. Profiling in vitro and in vivo has resulted in the identification of a compound with a longer duration of action and a lower oral side effect profile in rodents compared to budesonide.
تدمد:
0968-0896
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee9cfa7333a64f21e6202c4cf7fa8cc https://pubmed.ncbi.nlm.nih.gov/15351404
حقوق:
CLOSED
رقم الأكسشن:
edsair.doi.dedup.....6ee9cfa7333a64f21e6202c4cf7fa8cc
قاعدة البيانات:
OpenAIRE
