Influence of antihypertensive drugs on aortic and coronary effects of Ang-(1-7) in pressure-overloaded rats
| العنوان: | Influence of antihypertensive drugs on aortic and coronary effects of Ang-(1-7) in pressure-overloaded rats |
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| المؤلفون: | Gustavo Rodrigues Pedrino, Álvaro P. S. Souza, P.H. Alves, Larissa Matuda Macedo, Elizabeth Pereira Mendes, Diego Basile Colugnati, Allancer D C Nunes, Robson A.S. Santos, Carlos Henrique de Castro |
| المصدر: | Brazilian Journal of Medical and Biological Research Brazilian Journal of Medical and Biological Research, Vol 50, Iss 4 Brazilian Journal of Medical and Biological Research, Volume: 50, Issue: 4, Article number: e5520, Published: 23 MAR 2017 Brazilian Journal of Medical and Biological Research v.50 n.4 2017 Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, Captopril, Time Factors, Physiology, Angiotensin-Converting Enzyme Inhibitors, Blood Pressure, 030204 cardiovascular system & hematology, Pharmacology, Spironolactone, Biochemistry, 0302 clinical medicine, Thoracic aorta, Aorta, Abdominal, General Pharmacology, Toxicology and Pharmaceutics, lcsh:QH301-705.5, Antihypertensive drugs, Mineralocorticoid Receptor Antagonists, lcsh:R5-920, General Neuroscience, General Medicine, Angiotensin-(1-7), Calcium Channel Blockers, Coronary Vessels, Vasodilation, Cardiac hypertrophy, Losartan, medicine.anatomical_structure, Models, Animal, Aortic pressure, cardiovascular system, Renin-angiotensin system, lcsh:Medicine (General), hormones, hormone substitutes, and hormone antagonists, medicine.drug, Immunology, Biophysics, Ocean Engineering, Coronary artery, 03 medical and health sciences, medicine.artery, medicine, Animals, Amlodipine, Rats, Wistar, Antihypertensive Agents, Pressure overload, Aorta, business.industry, Reproducibility of Results, Biomedical Sciences, Cell Biology, Peptide Fragments, Coronary arteries, lcsh:Biology (General), Vasoconstriction, Angiotensin I, business, Angiotensin II Type 1 Receptor Blockers, 030217 neurology & neurosurgery |
| الوصف: | This study investigated the influence of antihypertensive drugs, such as angiotensin-converting enzyme inhibitors (ACEIs), AT1 receptor blockers (ARBs), voltage-gated L-type calcium channel blockers, and mineralocorticoid receptor antagonists (MRAs), on the effects of angiotensin-(1-7) [Ang-(1-7)] on aorta and coronary arteries from pressure-overloaded rats. Pressure overload was induced by abdominal aortic banding (AB). To evaluate the role of antihypertensive drugs on the effect of Ang-(1-7), AB male Wistar rats weighing 250–300 g were treated with vehicle or low doses (5 mg·kg-1·day-1, gavage) of losartan, captopril, amlodipine, or spironolactone. Isolated aortic rings and isolated perfused hearts under constant flow were used to evaluate the effect of Ang-(1-7) in thoracic aorta and coronary arteries, respectively. Ang-(1-7) induced a significant relaxation in the aorta of sham animals, but this effect was reduced in the aortas of AB rats. Chronic treatments with losartan, captopril or amlodipine, but not with spironolactone, restored the Ang-(1-7)-induced aorta relaxation in AB rats. The coronary vasodilatation evoked by Ang-(1-7) in sham rats was blunted in hypertrophic rats. Only the treatment with losartan restored the coronary vasodilatory effect of Ang-(1-7) in AB rat hearts. These data support a beneficial vascular effect of an association of Ang-(1-7) and some antihypertensive drugs. Thus, this association may have potential as a new therapeutic strategy for cardiovascular diseases. |
| وصف الملف: | text/html |
| تدمد: | 1414-431X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f23ad3d613652d399d304e7219ab938 https://pubmed.ncbi.nlm.nih.gov/28355350 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6f23ad3d613652d399d304e7219ab938 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1414431X |
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